Lipscomb entered the tournament as the defending Atlantic Sun Tournament champions, and as the 2018 ASUN regular season champions. Outscoring their opponents 4-1 in the process, Lipscomb successfully defended their ASUN title by winning the championship match against Stetson, 2-0. Lipscomb earned their second ever berth into the NCAA Tournament, where they upset Washington and FIU en route to a Sweet Sixteen run.