This article describes the knockout stage of the 2017–18 Women's EHF Champions League.^[1]

The top four placed teams from each of the two main round groups advanced to the knockout stage.

Group	First place	Second place	Third place	Fourth place
1	Győri Audi ETO KC	Rostov-Don	CSM București	FC Midtjylland
2	HC Vardar	Metz Handball	FTC-Rail Cargo Hungaria	ŽRK Budućnost

The first-placed team of each group faces the fourth-placed team, and the second-placed team will play against the third-placed team from the other group. After that a draw will be held to determine the pairings for the final four.

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
ŽRK Budućnost	48–56	Győri Audi ETO KC	20–26	28–30
FTC-Rail Cargo Hungaria	51–63	Rostov-Don	29–31	22–32
CSM București	54–48	Metz Handball	34–21	20–27
FC Midtjylland	48–56	HC Vardar	23–24	25–32

7 April 2018 19:00	ŽRK Buducnost	20–26	Győri Audi ETO KC	Morača Sports Center, Podgorica Attendance: 2,500 Referees: Leszczynski, Piechota (POL)
	Raičević 9	(9–12)	Amorim, Görbicz 8
	3× 3×	Report	4× 2×

14 April 2018 19:00	Győri Audi ETO KC	30–28	ŽRK Buducnost	Audi Aréna, Győr Attendance: 5,237 Referees: Christiansen, Hansen (DEN)
	Görbicz 11	(15–15)	Raičević 9
	3× 4×	Report	2× 4×

Győri ETO won 56–48 on aggregate.

7 April 2018 17:00	FTC-Rail Cargo Hungaria	29–31	Rostov-Don	OBO Aréna, Dabas Attendance: 2,489 Referees: Baumgart, Wild (GER)
	three players 4	(15–16)	Vyakhireva 8
	4× 4×	Report	4× 5× 1×

14 April 2018 15:00	Rostov-Don	32–22	FTC-Rail Cargo Hungaria	Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 3,500 Referees: Pandzić, Mosorinski (SRB)
	Vyakhireva 7	(20–12)	Jovanović 5
	3× 6× 1×	Report	3× 2×

Rostov-Don won 63–51 on aggregate.

6 April 2018 19:30	CSM București	34–21	Metz Handball	Sala Polivalentă, București Attendance: 4,874 Referees: Marić, Mašić (SRB)
	Neagu 10	(19–13)	Gros 9
	3× 2×	Report	4× 2×

15 April 2018 17:00	Metz Handball	27–20	CSM București	Arènes de Metz, Metz Attendance: 4,835 Referees: Kurtagic, Wetterwik (SWE)
	Houette 7	(14–9)	Neagu 8
	3× 1×	Report	3× 3×

CSM București won 54–48 on aggregate.

6 April 2018 19:00	FC Midtjylland	23–24	HC Vardar	Ikast-Brande Arena, Ikast Attendance: 2,509 Referees: Álvarez, López (ESP)
	Friis, Kristiansen 6	(16–13)	Cvijić 8
	2× 2×	Report	1× 2×

14 April 2018 17:00	HC Vardar	32–25	FC Midtjylland	Jane Sandanski Arena, Skopje Attendance: 4,300 Referees: Caçador, Nicolau (POR)
	Lekić 7	(17–12)	Kristiansen 9
	2× 2×	Report	2×

HC Vardar won 56–48 on aggregate.

The final four was held at the László Papp Budapest Sports Arena in Budapest, Hungary on 12 and 13 May 2018. The draw took place on 17 April 2018.^[2][3]

	Semifinals				Final
	12 May
	CSM București	20
					13 May
	Győri Audi ETO KC	26
					Győri Audi ETO KC (OT)	27
	12 May
					HC Vardar	26
	Rostov-Don	19
	HC Vardar	25
					Third place
					13 May
					CSM București	31
					Rostov-Don	30

12 May 2018 15:15	CSM București	20–26	Győri Audi ETO KC	László Papp Budapest Sports Arena, Budapest Attendance: 12,000 Referees: Jurinović, Mrvica (CRO)
	Neagu 6	(10–12)	Groot 7
	2× 2×	Report	4× 3×

12 May 2018 18:00	Rostov-Don	19–25	HC Vardar	László Papp Budapest Sports Arena, Budapest Attendance: 12,000 Referees: Florescu, Stoia (ROU)
	Ilyina 5	(7–10)	Lekić, Penezić 7
	4× 1×	Report	3× 4×

13 May 2018 15:15	CSM București	31–30	Rostov-Don	László Papp Budapest Sports Arena, Budapest Attendance: 12,000 Referees: Mitrović, Kažanegra (MNE)
	Jørgensen 7	(19–14)	Borshchenko, Sudakova 5
	3× 4×	Report	2×

13 May 2018 18:00	Győri Audi ETO KC	27–26 (ET)	HC Vardar	László Papp Budapest Sports Arena, Budapest Attendance: 12,000 Referees: Bonaventura, Bonaventura (FRA)
	Groot 9	(9–9)	Lekić 6
	3× 6×	Report	2× 4×
	FT: 20–20 ET: 7–6

• Final four website