Boca played two friendly games, the first one against Puebla F.C. in Mexico losing 1–0 on November 19 and the second one in Resistencia against a team of Liga Chaqueña de fútbol winning 3–2 on November 28.
Rodolfo Arruabarrena was sacked and is no longer the head coach of Boca; where he won 2 titles and managed 75 games, winning 47, drawing 13 and losing 15.[17] On March 1, Guillermo Barros Schelotto was announced as the new manager,[18] being his third time as manager in a professional football team. He returns to the club after his step as player between 1997 and 2007 where he won 16 titles. In the first match of the new manager, Boca played against Racing in a 0–0 draw on the second round of Copa Libertadores Group Stage. On the Round 6, Boca played against River Plate, the Superclásico, the most important match of Argentina; it was a 0–0 draw. Boca achieved another draw in the group stage of Copa Libertadores, 1–1 in La Paz against Bolívar. On March 14 Boca managed to win 2–1 against Unión. On March 20 Boca lost the match 0–2 against Lanús playing very bad.
April
The first match of April was a 3–0 victory over Atlético de Rafaela. On April 4 the third uniform was presented: it is black with a golden strip.[19] Boca won the first match in Copa Libertadores: 3–1 against Bolívar on the fourth match of the group. On April 10 Boca lost the match 0–2 against Tigre. On April 13 Boca qualified to the final stages of the Copa Libertadores after winning 1–0 in Avellaneda against Racing. In the 11 round Boca won 4–1 against Aldosivi. Boca finished the Group Stage of Copa Libertadores winning 6–2 against Deportivo Cali. The second Superclasico against River Plate was another 0–0 draw. In the first game of the Round of 16 of Copa Libertadores, Boca achieved a great victory 2–1 in Asunción against Cerro Porteño. In the round 13 of the local Tournament Boca lost 1–0 against Argentinos Juniors, playing with an alternative team.
May
In the second leg of the Round of 16 of Copa Libertadores, Boca won 3–1 against Cerro Porteño and advanced to the Quarterfinals. In the round 14 of the local tournament Boca played against Huracán in a 0–0 draw. In the first leg of the Copa Libertadores Quarterfinals played on May 12, Boca tied 1–1 in Montevideo against Nacional. On May 15, Boca played against Estudiantes (LP) and lost 3–1. On May 19 Boca advanced to the Semifinals of the Copa Libertadores after beating Nacional in the Penalty shoot-out. Boca played the last match of the local tournament and the season: it was a 0–0 draw against Defensa y Justicia.
1: There is a one-month break between the quarterfinals and semifinals due to the Copa América Centenario held in June, so the Semifinals belong to the next season.