The 2010–11 Cypriot Cup was the 69th edition of the Cypriot Cup. A total of 28 clubs entered the competition. It began on 10 November 2010 with the first round and concluded on 18 May 2011 with the final which was held at GSZ Stadium. Omonia won their 13th Cypriot Cup trophy after beating Apollon 4–3 on penalties in the final.
The competition consisted of five rounds. All rounds, except the final, were played in a two-legged format, each team playing a home and an away match against their opponent. The team which scored more goals on aggregate, was qualifying to the next round. If the two teams scored the same number of goals on aggregate, then the team which scored more goals away from home was advancing to the next round.
If both teams had scored the same number of home and away goals, then extra time was following after the end of the second leg match. If during the extra thirty minutes both teams had managed to score, but they had scored the same number of goals, then the team who scored the away goals was advancing to the next round (i.e. the team which was playing away). If there weren't scored any goals during extra time, the qualifying team was determined by penalty shoot-out.
The Cypriot First Division teams were not drawn together and played the second leg at home. The first legs were played on November 10, 2010. The second legs were played on November 24, December 1 and 8, 2010.
In the second round participated the winners of the first round ties and the four first division teams which were qualified for 2009–10 Cypriot Cup's semifinals. The first legs were played on January 12,19,26, 2011. The second legs were played on January 19,26, February 2,16, 2011.
