Women's singles
2010 Mutua Madrileña Madrid Open
Final
Champion	Aravane Rezaï
Runner-up	Venus Williams
Score	6–2, 7–5
Events
Singles men women Doubles men women
← 2009 · Mutua Madrileña Madrid Open · 2011 →

Aravane Rezaï defeated Venus Williams in the final, 6–2, 7–5 to win the women's singles tennis title at the 2010 Madrid Open.

Dinara Safina was the defending champion, but lost to Klára Zakopalová in the first round.

The four Rome semifinalists received a bye into the second round. They are as follows:

• Serena Williams (third round)
• Jelena Janković (quarterfinals)
• Ana Ivanovic (second round)
• María José Martínez Sánchez (second round)

	Quarterfinals							Semifinals							Final
	16	Nadia Petrova	1	6	4
		Lucie Šafářová	6	1	6
									Lucie Šafářová	1	0r
									Aravane Rezaï	6	0
		Aravane Rezaï	7	6
	7	Jelena Janković	5	4
																Aravane Rezaï	6	7
															4	Venus Williams	2	5
	8	Samantha Stosur	3	3
	4	Venus Williams	6	6
								4	Venus Williams	6	6
									Shahar Pe'er	3	0
		Shahar Pe'er	6	3	6
	13	Li Na	4	6	4

	First round							Second round							Third round							Quarterfinals
								1	S Williams	62	7	7
		V Dushevina	6	6					V Dushevina	7	65	65
	Q	K Flipkens	2	1											1	S Williams	6	2	3
		A Pavlyuchenkova	6	7											16	N Petrova	4	6	6
		D Hantuchová	4	62					A Pavlyuchenkova	2	5
		E Vesnina	6	2	3			16	N Petrova	6	7
	16	N Petrova	4	6	6																	16	N Petrova	1	6	4
	11	M Sharapova	4	3																			L Šafářová	6	1	6
		L Šafářová	6	6					L Šafářová	4	6	7
		O Govortsova	7	6					O Govortsova	6	2	5
	LL	T Garbin	5	2												L Šafářová	64	6	7
		A Dulgheru	6	0												A Dulgheru	7	1	66
		M Czink	1	0r					A Dulgheru	6	3	7
		A Wozniak	0	1				6	E Dementieva	1	6	5
	6	E Dementieva	6	6

	First round							Second round							Third round							Quarterfinals
	3	D Safina	61	63
	Q	K Zakopalová	7	7				Q	K Zakopalová	3	5
		J Henin	6	5	0				A Rezaï	6	7
		A Rezaï	4	7	6											A Rezaï	6	7
		A Petkovic	63	6	7											A Petkovic	4	68
		S Errani	7	1	5				A Petkovic	7	6
		S Cîrstea	1	6	1			14	F Pennetta	63	3
	14	F Pennetta	6	1	6																		A Rezaï	7	6
	12	M Bartoli	3	6	6																	7	J Janković	5	4
		P Hercog	6	4	4			12	M Bartoli	2	0
		J Zheng	6	3	2				A Medina Garrigues	6	6
		A Medina Garrigues	3	6	6											A Medina Garrigues	2	0
															7	J Janković	6	6
								WC	A Ivanovic	6	4	1
								7	J Janković	4	6	6

	First round							Second round							Third round							Quarterfinals
	8	S Stosur	7	7
		G Dulko	63	5				8	S Stosur	7	6
									MJ Martínez Sánchez	62	4
															8	S Stosur	7	6
		Á Szávay	2r													P Schnyder	63	2
		P Schnyder	5						P Schnyder	3	6	6
		M Kirilenko	2	2				9	A Radwańska	6	4	4
	9	A Radwańska	6	6																		8	S Stosur	3	3
	15	F Schiavone	6	6																		4	V Williams	6	6
	Q	A Cornet	2	2				15	F Schiavone	6	6
		Y Shvedova	4	6	3			WC	S Bammer	2	1
	WC	S Bammer	6	3	6										15	F Schiavone	6	1	2
		V Zvonareva	6	6											4	V Williams	3	6	6
		M Oudin	3	4					V Zvonareva	5	3
	Q	S Vögele	4	2				4	V Williams	7	6
	4	V Williams	6	6

	First round							Second round							Third round							Quarterfinals
	5	S Kuznetsova	3	6	0
		S Pe'er	6	2	6				S Pe'er	7	6
	Q	A Amanmuradova	3	2					A Kleybanova	64	0
		A Kleybanova	6	6												S Pe'er	7	6
	WC	V Ruano Pascual	3	2											WC	A Parra Santonja	5	2
	WC	A Parra Santonja	6	6				WC	A Parra Santonja	1	7	6
	WC	S Peng	3					WC	S Peng	6	61	3
	10	V Azarenka	0r																				S Pe'er	6	3	6
	13	N Li	6	6																		13	N Li	4	6	4
	Q	B García Vidagany	0	2				13	N Li	6	3	7
		D Cibulková	6	6					D Cibulková	2	6	5
	Q	I Benešová	2	2											13	N Li	6	6
		M Rybáriková	6	1	4											A Bondarenko	3	4
		A Bondarenko	2	6	6				A Bondarenko	6	6
	Q	P Kvitová	4	2				2	C Wozniacki	2	3
	2	C Wozniacki	6	6

• Main Draw
• Qualifying Draw