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Singles
2008 Western & Southern Financial Group Masters
Final
Champion	Andy Murray
Runner-up	Novak Djokovic
Score	7–6(7–4), 7–6(7–5)
Details
Draw	56
Seeds	16
Events
Singles Doubles
← 2007 · Western & Southern Financial Group Masters · 2009 →

Andy Murray defeated Novak Djokovic in the final, 7–6^(7–4), 7–6^(7–5) to win the men's singles tennis title at the 2008 Cincinnati Masters. It was his first Masters title. Rafael Nadal's 32 match winning-streak ended in the semifinals when he was defeated by Djokovic.

Roger Federer was the defending champion, but lost in the third round to Ivo Karlović.

The top eight seeds receive a bye into the second round.

	Quarterfinals							Semifinals							Final
	16	Ivo Karlović	78	77
		Philipp Kohlschreiber	66	63
								16	Ivo Karlović	4	4
								8	Andy Murray	6	6
		Carlos Moyá	6	3	1
	8	Andy Murray	2	6	6
															8	Andy Murray	77	77
															3	Novak Djokovic	64	65
		Ernests Gulbis	3	4
	3	Novak Djokovic	6	6
								3	Novak Djokovic	6	7
								2	Rafael Nadal	1	5
		Nicolás Lapentti	63	1
	2	Rafael Nadal	77	6

	First round							Second round							Third round							Quarterfinals
								1	R Federer	62	77	6
	Q	J Björkman	0	65					R Ginepri	77	65	0
		R Ginepri	6	77											1	R Federer	66	6	65
	LL	P Capdeville	7	2	2										16	I Karlović	78	4	77
		J Acasuso	5	6	6				J Acasuso	3	63
		T Bellucci	3	4				16	I Karlović	6	77
	16	I Karlović	6	6																		16	I Karlović	78	77
	12	T Robredo	6	6																			P Kohlschreiber	66	63
		M Fish	2	2				12	T Robredo	66	4
		J Benneteau	0	3					R Söderling	78	6
		R Söderling	6	6												R Söderling	64	7	68
		P Kohlschreiber	6	6												P Kohlschreiber	77	5	710
	Q	M Yani	3	4					P Kohlschreiber	6	6
								LL	W-s Jun	2	2

	First round							Second round							Third round							Quarterfinals
								4	N Davydenko	68	6	2
		J Tipsarević	65	5					C Moyá	710	4	6
		C Moyá	77	7												C Moyá	6	77
	WC	J Isner	77	6												I Andreev	4	62
	Q	A Stoppini	62	3				WC	J Isner	6	68	5
		I Andreev	77	64	77				I Andreev	3	710	7
	15	R Štěpánek	64	77	63																		C Moyá	6	3	1
	11	R Gasquet	3	6	1																	8	A Murray	2	6	6
		M Llodra	6	1	0r			11	R Gasquet	68	0
		D Tursunov	77	6					D Tursunov	710	6
	WC	M Safin	65	4												D Tursunov	3	3
		S Querrey	6	4	6										8	A Murray	6	6
		P-H Mathieu	4	6	3				S Querrey	63	1
								8	A Murray	77	6

	First round							Second round							Third round							Quarterfinals
								7	J Blake	6	6
	LL	R Ram	65	4					G Simon	4	3
		G Simon	77	6											7	J Blake	4	6	3
		J Nieminen	67	2												E Gulbis	6	1	6
		E Gulbis	79	6					E Gulbis	6	3	77
		T Johansson	64	77	3			LL	A Clément	4	6	65
	LL	A Clément	77	65	6																		E Gulbis	3	4
	13	F González	3	6	3																	3	N Djokovic	6	6
		T Berdych	6	3	6				T Berdych	7	5	5
		F López	5	5					A Seppi	5	7	7
		A Seppi	7	7												A Seppi	1	2
	Q	K Anderson	3	61											3	N Djokovic	6	6
		S Bolelli	6	77					S Bolelli	62	62
								3	N Djokovic	77	77

	First round							Second round							Third round							Quarterfinals
								5	D Ferrer	62	6	3
		N Lapentti	77	6					N Lapentti	77	3	6
		M Čilić	65	2												N Lapentti	6	7
	WC	J Levine	3	4											10	F Verdasco	3	5
	Q	C Guccione	6	6				Q	C Guccione	64	64
	Q	V Estrella	3	5				10	F Verdasco	77	77
	10	F Verdasco	6	7																			N Lapentti	63	1
	14	M Youzhny	62	6	4																	2	R Nadal	77	6
		T Haas	77	2	6				T Haas	5
		G Monfils	6	6					G Monfils	1r
	WC	D Young	1	1												T Haas	4	60
	Q	B Becker	6	66	4										2	R Nadal	6	77
		F Serra	4	78	6				F Serra	0	1
								2	R Nadal	6	6

• Draw
• Qualifying Draw