The 2006 Iowa State Cyclones football team represented Iowa State University during the 2006 NCAA Division I FBS football season. They played their home games at Jack Trice Stadium in Ames, Iowa. They participated as members of the Big 12 Conference in the North Division. They were coached by head coach Dan McCarney, who was in his final season as head coach of the Cyclones.

Date	Time	Opponent	Site	TV	Result	Attendance
August 31	7:00 p.m.	Toledo*	Jack Trice Stadium Ames, IA	MC22	W 45–43 OT	42,531
September 9	6:00 p.m.	UNLV*	Jack Trice Stadium Ames, IA		W 16–10	45,795
September 16	11:00 a.m.	at No. 16 Iowa*	Kinnick Stadium Iowa City, IA (Battle for the Cy-Hawk Trophy)	ESPN	L 17–27	70,585
September 23	2:30 p.m.	at No. 7 Texas	Darrell K Royal–Texas Memorial Stadium Austin, TX	ABC	L 14–37	88,792
September 30	6:00 p.m.	No. 13 (FCS) Northern Iowa*	Jack Trice Stadium Ames, IA		W 28–27	55,518
October 7	7:00 p.m.	No. 22 Nebraska	Jack Trice Stadium Ames, IA	ABC	L 14–28	55,338
October 14	11:30 a.m.	at No. 23 Oklahoma	Gaylord Family Oklahoma Memorial Stadium Norman, OK	FSN	L 9–34	84,152
October 21	2:30 p.m.	Texas Tech	Jack Trice Stadium Ames, IA		L 26–42	44,112
October 28	2:35 p.m.	at Kansas State	Bill Snyder Family Football Stadium Manhattan, KS (rivalry)		L 10–31	44,729
November 4	1:00 p.m.	Kansas	Jack Trice Stadium Ames, IA		L 10–41	40,272
November 11	2:00 p.m.	at Colorado	Folsom Field Boulder, CO		L 16–35	43,056
November 18	1:00 p.m.	Missouri	Jack Trice Stadium Ames, IA (Battle for the Telephone Trophy)		W 21–16	39,631
*Non-conference game Homecoming Rankings from AP Poll released prior to the game All times are in Central time

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