The 1995 Iowa State Cyclones football team represented Iowa State University during the 1995 NCAA Division I-A football season. They played their home games at Cyclone Stadium in Ames, Iowa. They participated as members of the Big Eight Conference. The team was coached by first year head coach Dan McCarney.

Date	Time	Opponent	Site	TV	Result	Attendance
August 31	7:00 p.m.	Ohio*	Cyclone Stadium Ames, IA		W 36–21	32,817
September 9	7:30 p.m.	at TCU*	Amon G. Carter Stadium Fort Worth, TX		L 10–27	35,185
September 16	11:00 a.m.	Iowa*	Cyclone Stadium Ames, IA (Battle for the Cy-Hawk Trophy)	ABC	L 10–27	49,714
September 23	1:00 p.m.	UNLV*	Cyclone Stadium Ames, IA		W 57–30	37,619
October 7	1:00 p.m.	No. 14 Oklahoma	Cyclone Stadium Ames, IA	KWTV	L 26–39	45,731
October 14	1:00 p.m.	at No. 10 Kansas	Memorial Stadium Lawrence, KS		L 7–34	43,000
October 21	11:00 a.m.	No. 9 Colorado	Cyclone Stadium Ames, IA	PSN	L 28–50	34,669
October 28	1:00 p.m.	Oklahoma State	Cyclone Stadium Ames, IA		W 38–14	34,281
November 4	1:00 p.m.	at No. 1 Nebraska	Memorial Stadium Lincoln, NE		L 14–73	75,505
November 11	1:00 p.m.	No. 7 Kansas State	Cyclone Stadium Ames, IA (rivalry)		L 7–49	27,356
November 18	1:00 p.m.	at Missouri	Faurot Field Columbia, MO (rivalry)		L 31–45	33,266
*Non-conference game Homecoming Rankings from AP Poll released prior to the game All times are in Central time

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