2-alkenal reductase
Leukotriene B4 12-hydroxydehydrogenase (NADP-dependent) dimer, Human
Identifiers
EC no.	1.3.1.74
CAS no.	9032-20-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 2-alkenal reductase (EC 1.3.1.74) is an enzyme that catalyzes the chemical reaction

n-alkanal + NAD(P)+ ${\displaystyle \rightleftharpoons }$ alk-2-enal + NAD(P)H + H⁺

The 3 substrates of this enzyme are n-alkanal, NAD⁺, and NADP⁺, whereas its 4 products are alk-2-enal, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is n-alkanal:NAD(P)+ 2-oxidoreductase. Other names in common use include NAD(P)H-dependent alkenal/one oxidoreductase, and NADPH:2-alkenal alpha,beta-hydrogenase.

As of late 2007, three structures have been solved for this class of enzymes, with PDB accession codes 2DM6, 2J3J, and 2J3K.

• Mano J, Torii Y, Hayashi S-I, et al. (2002). "The NADPH:quinone oxidoreductase P1-zeta-crystallin in Arabidopsis catalyzes the alpha,beta-hydrogenation of 2-alkenals: detoxication of the lipid peroxide-derived reactive aldehydes". Plant Cell Physiol. 43 (12): 1445–55. doi:10.1093/pcp/pcf187. PMID 12514241.
• Dick RA, Kwak MK, Sutter TR, Kensler TW (2001). "Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase". J. Biol. Chem. 276 (44): 40803–10. doi:10.1074/jbc.M105487200. PMID 11524419.