2'-phosphotransferase

2'-phosphotransferase
Identifiers
EC no.2.7.1.160
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

In enzymology, a 2'-phosphotransferase (EC 2.7.1.160) is an enzyme that catalyzes the chemical reaction

2'-phospho-[ligated tRNA] + NAD+ mature tRNA + ADP-ribose 1,2-phosphate + nicotinamide + H2O

Thus, the two substrates of this enzyme are [[2'-phospho-[ligated tRNA]]] and NAD+, whereas its 4 products are mature tRNA, ADP-ribose 1'',2''-phosphate, nicotinamide, and H2O.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is 2'-phospho-[ligated tRNA]:NAD+ phosphotransferase. Other names in common use include yeast 2'-phosphotransferase, Tpt1, Tpt1p, and 2'-phospho-tRNA:NAD+ phosphotransferase.

References


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