Venus Williams defeated Anna Kournikova in the final, 2–6, 6–4, 6–1 to win the women's singles tennis title at the 1998 Miami Open.
Martina Hingis was the defending champion, but lost in the semifinals to Williams.
Seeds
A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated. All thirty-two seeds received a bye to the second round.