February 27 – Jack Quinn, a pitcher for the Boston Braves, jumped from the National League to the Baltimore Terrapins of the Federal League. Quinn was one of many players from the AL and NL who jumped leagues.
July 1 – Harry Kingman pitch hits for the New York Yankees in their 7–4 loss to the Washington Senators. Though Kingman appeared in four games in his MLB career and never got a hit, he was the first player born in China to play major league baseball.
July 17 – Red Murray of the New York Giants catches game winning catch and is immediately struck by lightning.
August 27 – Fred McMullin makes his MLB debut for the Detroit Tigers in their 9–2 loss to the Boston Red Sox. McMullin would later be infamous as one of the players banned from baseball for conspiring to throw the 1919 World Series.
October 13 – The Boston Braves defeat the Philadelphia Athletics, 3–1, in Game 4 of the World Series to win their first World Championship, four games to none. This was the first four-game sweep in World Series history. The Cubs had defeated the Tigers four games to none in 1907, but Game 1 had ended in a tie before the Cubs won the next four in a row.
January 11 – Walt Goldsby, 52, outfielder who hit .236 for five teams in two different leagues between 1884 and 1888.
January 13 – Aaron Clapp, 57, first baseman for the 1879 Troy Trojans of the National League.
January 20 – Pat Lyons, 53, Canadian second baseman who played for the Cleveland Spiders of the National League in 1890.
February 1 – Sam Weaver, 58, pitcher who posted a 68–80 record and a 3.21 ERA with five teams in four different leagues from 1875 to 1886.
February 9 – Buster Brown, 32, National League pitcher who had a 51–103 record and a 3.21 ERA for the St. Louis Cardinals (1905–'07), Philadelphia Phillies (1907–'09) and Boston Doves/Braves (1909–13).
February 9 – Jack Farrell, 56, second baseman for 11 seasons (1879–1889), who played bulk of his career with the Providence Grays.
February 21 – Farmer Vaughn, 49, catcher who hit .274 with 21 home runs and 525 RBI in 925 games for five teams from 1886 to 1899.
February 23 – Nat Jewett, 69, catcher for the 1872 Brooklyn Eckfords of the National Association.
February 28 – Art Sladen, 53, outfielder for the Boston Reds of the Union Association in 1884.
March 24 – Jack Brennan, 50, catcher/infielder who played from 1884 to 1890 with four teams in four different leagues.
April 1 – Rube Waddell, 37, pitcher for the Philadelphia Athletics who led AL in strikeouts six consecutive years, including modern record of 349 in 1904; four-time 20-game winner led AL in ERA twice with career 2.16 mark, best ever by left-hander with 1500 innings; 2316 strikeouts ranked third in history upon retirement, 50 shutouts ranked fifth; first major leaguer to strike out a side on nine pitches. According to Lee Allen, in The American League Story (1961), there were those who considered it appropriate that Waddell should die on April Fool's Day.
April 7 – Charlie Ganzel, 51, catcher for four different teams during fourteen seasons, and a member of the 1887 Detroit Wolverines National League champion team that won the first ever World Series, beating the St. Louis Browns ten games to five.
April 16 – Podge Weihe, 51, American Association outfielder who hit .254 in two seasons with the Indianapolis Hoosiers (1883) and Cincinnati RedStockings (1884).
April 27 – Herb Worth, 66, outfielder for the 1872 Brooklyn Atlantics of the National Association .
May–August
May 8 – George Fox, 45, first baseman for the Louisville Colonels of the American Association (1891) and the Pittsburgh Pirates of the National League (1899).
May 26 – Jumbo Latham, 61, first baseman who hit .247 in 334 games for five different teams from 1875 to 1884, while managing two of them (1875, 1882).
June 16 – Bert Dorr, 52, pitcher for the 1882 St. Louis Browns.
July 5 – Wee Willie Mills, 36, pitcher for the National League New York Giants in 1901.
July 9 – Ossee Schreckengost, 39, catcher for eleven seasons, most notably with the Philadelphia Athletics from 1902 to 1908, who pioneered one-handed style and batted .300 twice.
August 1 – Gid Gardner, 55, outfielder/pitcher from 1879 to 1888, who hit a .233 average and had a 2–10 record for eight teams in three different leagues.
August 1 – Con Murphy, 50, pitcher who posted a 4–13 record with the Philadelphia Quakers (1884) and Brooklyn Ward's Wonders (1890).
August 17 – Harry Steinfeldt, 36, third baseman for the Cincinnati Reds and Chicago Cubs who led National League in hits, doubles and RBI once each, batting .300 twice, and hit .471 in the 1907 World Series to lead the Cubs to the championship.
September–December
September 2 – Al Metcalf, 61, appeared in eight games for the 1875 New York Mutuals.
September 9 – Willie Garoni, 37, pitcher for the 1899 New York Giants of the National League.
September 14 – Jim McDonald, 54, third baseman who played from 1884 to 1885 for three teams in three different leagues.
November 2 – Jack Sheridan, 52, American League umpire since the league's 1901 formation, previously in the Players' League and National League, who officiated in four of the first seven World Series, and introduced the practice of crouching behind the catcher when calling balls and strikes.
November 9 – Danny Green, 38, outfielder for the Orphans and White Sox Chicago teams and a four-time .300 hitter who died following complications related to a beaning.
November 10 – Jack Heinzman, 51, first baseman for the 1886 Louisville Colonels of the American Association.
November 10 – Heinie Reitz, 47, National League second baseman for the Orioles, Senators and Pirates from 1893 to 1899, who hit .292 in 724 games and led the league with 31 triples in 1894.
November 28 – Tug Wilson, 54, outfielder and catcher for the 1884 Brooklyn Atlantics.
December 11 – Harry Burrell, 47, pitcher who posted a 4–2 record and a 4.81 ERA with the 1891 St. Louis Browns of the American Association.
December 22 – Phil Powers, 60, catcher who played from 1878 to 1885 for five different teams in the National League and American Association.
December 31 – John Farrow, 61, National Association catcher for the Elizabeth Resolutes (1873) and Brooklyn Atlantics (1874, 1884).
December 31 – John O'Brien, 63, outfielder for the 1884 Baltimore Monumentals of the Union Association.
