In enzymology, a 1-alkenylglycerophosphoethanolamine O-acyltransferase (EC 2.3.1.121) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 1-alkenylglycerophosphoethanolamine ${\displaystyle \rightleftharpoons }$ CoA + 1-alkenyl-2-acylglycerophosphoethanolamine

Thus, the two substrates of this enzyme are acyl-CoA and 1-alkenylglycerophosphoethanolamine, whereas its two products are CoA and 1-alkenyl-2-acylglycerophosphoethanolamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase. This enzyme participates in ether lipid metabolism.

• Arthur G, Page L, Choy PC (1987). "Acylation of 1-alkenylglycerophosphoethanolamine and 1-acylglycerophosphoethanolamine in guinea-pig heart microsomes". Biochim. Biophys. Acta. 921 (2): 259–65. doi:10.1016/0005-2760(87)90026-9. PMID 3651487.