1-Hydroxycarotenoid 3,4-desaturase

1-hydroxycarotenoid 3,4-desaturase
Identifiers
EC no.1.3.99.27
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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1-Hydroxycarotenoid 3,4-desaturase (EC 1.3.99.27, CrtD, hydroxyneurosporene desaturase, carotenoid 3,4-dehydrogenase, 1-hydroxy-carotenoid 3,4-dehydrogenase) is an enzyme with systematic name 1-hydroxy-1,2-dihydrolycopene:acceptor oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

1-hydroxy-1,2-dihydrolycopene + acceptor 1-hydroxy-3,4-didehydro-1,2-dihydrolycopene + reduced acceptor

The enzymes from Rubrivivax gelatinosus and Rhodobacter sphaeroides acts primarily on acyclic carotenoids.

References

  1. ^ Teramoto M, Rählert N, Misawa N, Sandmann G (July 2004). "1-Hydroxy monocyclic carotenoid 3,4-dehydrogenase from a marine bacterium that produces myxol". FEBS Letters. 570 (1–3): 184–8. doi:10.1016/j.febslet.2004.05.085. PMID 15251462.
  2. ^ Steiger S, Astier C, Sandmann G (July 2000). "Substrate specificity of the expressed carotenoid 3,4-desaturase from Rubrivivax gelatinosus reveals the detailed reaction sequence to spheroidene and spirilloxanthin". The Biochemical Journal. 349 (Pt 2): 635–40. doi:10.1042/0264-6021:3490635. PMC 1221188. PMID 10880364.
  3. ^ Albrecht M, Ruther A, Sandmann G (December 1997). "Purification and biochemical characterization of a hydroxyneurosporene desaturase involved in the biosynthetic pathway of the carotenoid spheroidene in Rhodobacter sphaeroides". Journal of Bacteriology. 179 (23): 7462–7. PMC 179698. PMID 9393712.