The enzyme 1,2-α-L-fucosidase (EC 3.2.1.63) catalyzes the following chemical reaction:

methyl-2-α-L-fucopyranosyl-β-D-galactoside + H₂O ${\displaystyle \rightleftharpoons }$ L-fucose + methyl β-D-galactoside

It belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name is 2-α-L-fucopyranosyl-β-D-galactoside fucohydrolase. Other names in common use include almond emulsin fucosidase, and α-(1→2)-L-fucosidase.

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2EAB, 2EAC, 2EAD, and 2EAE.

• Bahl OP (1970). "Glycosidases of Aspergillus niger. II. Purification and general properties of 1,2-α-L-fucosidase". J. Biol. Chem. 245 (2): 299–304. doi:10.1016/S0021-9258(18)63394-0. PMID 5460888.
• Ogata-Arakawa M, Muramatsu T, Kobata A (1977). "α-L-Fucosidases from almond emulsin: characterization of the two enzymes with different specificities". Arch. Biochem. Biophys. 181 (1): 353–8. doi:10.1016/0003-9861(77)90514-8. PMID 18111.
• Reglero A, Cabezas JA (1976). "Glycosidases of molluscs. Purification and properties of α-L-fucosidase from Chamelea gallina L". Eur. J. Biochem. 66 (2): 379–87. doi:10.1111/j.1432-1033.1976.tb10527.x. PMID 7458.