CpG-Oligonukleotid 7909

Nukleinsäure
TCGTCGTTTTGTCGTTTTGTCGTT
Allgemeines
Freiname Agatolimod[1]
Andere Namen
  • ProMune
  • ODN 7909
  • PF 3512676[2]
Identifikatoren
GenBank

LQ957673.1

CAS-Nummer

207623-20-9

PubChem

56841790

Wirkstoffdaten
DrugBank

DB15018

Eigenschaften
Größe

24 Nukleotide, 7698,21 Da

Taxon

synthetisch

CpG-Oligonukleotid 7909 (auch CpG 7909, Agatolimod) ist ein CpG-Oligonukleotid, das an den TLR9 bindet und daher in der Immunologie und Pharmakologie als Adjuvans verwendet wird.

Eigenschaften

Wirkungen unterschiedlicher CpG-Klassen

CpG 7909 wird synthetisch per Phosphoramidit-Methode hergestellt. Es hat die Sequenz: 5′-TCGTCGTTTTGTCGTTTTGTCGTT-3′. Das Phosphodiester-Desoxyribose-Rückgrat ist hierbei zu einem Phosphorthioat modifiziert. Dabei wird ein nicht an der Phosphatbrücke beteiligtes Sauerstoffatom durch ein Schwefelatom ersetzt.[3] Dadurch wird es resistent gegenüber DNasen.

Anwendungen

CpG 7909 wird in einer Variante des Anthraximpfstoffs BioThrax verwendet.[4]

Literatur

Einzelnachweise

  1. INN Recommended List 60, World Health Organisation (WHO), 9. September 2008.
  2. PubChem: Agatolimod sodium | C238H291N75Na23O127P23S23 | CID 56841789 - PubChem, abgerufen am 20. August 2023.
  3. Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto jr., Lubert Stryer: Stryer Biochemie. Katalytische Strategien. 8. Auflage. Springer, 2018, ISBN 978-3-662-54619-2, S. 321, doi:10.1007/978-3-662-54620-8_9.
  4. Jingxing Yang, Jen-Chih Tseng, Guann-Yi Yu, Yunping Luo, Chi-Ying F. Huang, Yi-Ren Hong, Tsung-Hsien Chuang: Recent Advances in the Development of Toll-like Receptor Agonist-Based Vaccine Adjuvants for Infectious Diseases. In: Pharmaceutics. 2022, Band 14, Nummer 2, S. 423 doi:10.3390/pharmaceutics14020423. PMID 35214155. PMC 8878135 (freier Volltext).

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