Pilokarpin

Pilokarpin
Schéma chemické struktury
Název podle IUPAC(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]oxolan-2-on
Kódy
Číslo CAS92-13-7
ChEMBL IDCHEMBL550
ChemSpider ID5699
PubChem5910
Chemie
Sumární vzorecC₁₁H₁₆N₂O₂
SMILESCCC1C(COC1=O)CC2=CN=CN2C
InChIInChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1
Molární hmotnost208,121 Da
Farmakologie
Indikacerakovina hlavy a krku, angle-closure glaucoma a glaukom
Některá data mohou pocházet z datové položky.

Pilokarpin (systematický název (3S,4R)-3-ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-on) je parasympatomimetický alkaloid získávaný z listů tropických amerických keřů rodu Pilocarpus. Pilokarpin je neselektivní agonista muskarinových receptorů[1] v parasympatickém nervovém systému, při povrchové terapeutické aplikaci (například při glaukomu nebo xerostomii) působí na muskarinovém acetylcholinovém receptoru M3.[2]

Reference

V tomto článku byl použit překlad textu z článku Pilocarpine na anglické Wikipedii.

  1. ↑ Spalding et al. 2002
  2. ↑ Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0-443-07145-4, 5:th ed., Churchill Livingstone 2003) Page 144

Externí odkazy

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