Kanabinoidní receptor

CB1 a CB2 struktury.

Kanabinoidní receptory jsou receptory spřažené s G-proteinem endokanabinoidního systému, které jsou zapojeny v řadě fyziologických procesů obratlovců, včetně chuti, vnímání bolesti, nálady a paměti.[1]

Kanabinoidní receptory jsou aktivovány třemi hlavními skupinami ligandů: endokanabinoidy vlastními organismu, rostlinnými kanabinoidy (fytokanabinoidy, např. kanabidiol z konopí) a syntetickými kanabinoidy (např. HU-210). Všechny endokanabinoidy a fytokanabinoidy jsou lipofilní látky, tedy v tuku rozpustné sloučeniny.

V současné době (rok 2018) jsou známy dva subtypy kanabinoidních receptorů, označované jako CB1 a CB2. CB1 receptor je exprimován primárně v centrální nervové soustavě (CNS), dále v plicích, játrech a ledvinách. CB2 receptor je exprimován především buňkami imunitního systému a v krvetvorných buňkách.[2]

Reference

V tomto článku byl použit překlad textu z článku Cannabinoid receptor na anglické Wikipedii.

  1. ↑ AIZPURUA-OLAIZOLA, Oier; ELEZGARAI, Izaskun; RICO-BARRIO, Irantzu; ZARANDONA, Iratxe; ETXEBARRIA, Nestor; USOBIAGA, Aresatz. Targeting the endocannabinoid system: future therapeutic strategies. Drug Discovery Today. 2016. Dostupné online. DOI 10.1016/j.drudis.2016.08.005. PMID 27554802. 
  2. ↑ Pacher P, Mechoulam R. Is lipid signaling through cannabinoid 2 receptors part of a protective system?. Prog Lipid Res.. 2011, s. 193–211. DOI 10.1016/j.plipres.2011.01.001. PMID 21295074. 

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