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ZGPAT
| ZGPAT |
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| | | Identifikatori |
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| Aliasi | ZGPAT |
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| Vanjski ID-jevi | MGI: 2449939 HomoloGene: 41874 GeneCards: ZGPAT |
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| | | | Ontologija gena |
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| Molekularna funkcija | • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific DNA binding
• vezivanje sa DNK
• GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific
• GO:0001948, GO:0016582 vezivanje za proteine
• vezivanje iona metala
• nucleic acid binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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| Ćelijska komponenta | • jedro
• ćelijska membrana
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| Biološki proces | • negative regulation of epidermal growth factor-activated receptor activity
• GO:0045996 negative regulation of transcription, DNA-templated
• GO:0009373 regulation of transcription, DNA-templated
• GO:1901227 negative regulation of transcription by RNA polymerase II
• transcription, DNA-templated
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| Izvori:Amigo / QuickGO |
| | Ortolozi |
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| Vrste | Čovjek | Miš |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNK) | | |
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| RefSeq (bjelančevina) | | |
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| Lokacija (UCSC) | Chr 20: 63.71 – 63.74 Mb | Chr 2: 181.01 – 181.03 Mb |
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| PubMed pretraga | [3] | [4] |
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| Wikipodaci | |
CCCH-tip cinkovog prsta sa G-parčetom domen-sadržavajućeg proteina je protein koji je kod ljudi kodiran genom ZGPAT.[5][6]
Ontologija
- Molekulska funkcija
- GO: 0001131, GO: 0001151, GO: 0001130, GO: 0001204
- Aktivnost DNK-vezujućeg transkripcijskog faktora
- GO: 0000980 RNA polimeraza II za specifično za sekvencu cis-regulatorno područje vezivanja DNK
- vezanje DNK specifično za sekvence
- Vezanje DNK
- GO: 0001078, GO: 0001214, GO: 0001206 Represorska aktivnost transkripcije koja veže DNK, specifična za RNK polimerazu II
- GO: 0001948 vezanje za proteine
- vezanje metalnih iona
- vezanje nukleinske kiseline
- GO: 0001200, GO: 0001133, GO: 0001201 aktivnost transkripcionog faktora koji veže DNK, specifična za RNA polimerazu II
- Ćelijska komponenta
- Biološki proces
- negativna regulacija aktivnosti receptora aktiviranog epidermnim faktorom rasta
- negativna regulacija transkripcije, sa predloškom DNK
- regulacija transkripcije, sa predloškom DNK
- negativna regulacija transkripcije RNK-polimerazom II
- transkripcija, DNK predložak
- Izvori: Amigo / QuickGO
Aminokiselinska sekvenca
- Simboli
| 10 | | 20 | | 30 | | 40 | | 50 |
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| MDEESLESAL | | QTYRAQLQQV | | ELALGAGLDS | | SEQADLRQLQ | | GDLKELIELT |
| EASLVSVRKS | | SLLAALDEER | | PGRQEDAEYQ | | AFREAITEAV | | EAPAAARGSG |
| SETVPKAEAG | | PESAAGGQEE | | EEGEDEEELS | | GTKVSAPYYS | | SWGTLEYHNA |
| MVVGTEEAED | | GSAGVRVLYL | | YPTHKSLKPC | | PFFLEGKCRF | | KENCRFSHGQ |
| VVSLDELRPF | | QDPDLSSLQA | | GSACLAKHQD | | GLWHAARITD | | VDNGYYTVKF |
| DSLLLREAVV | | EGDGILPPLR | | TEATESDSDS | | DGTGDSSYAR | | VVGSDAVDSA |
| QSSALCPSLA | | VVGSDAVDSG | | TCSSAFAGWE | | VHTRGIGSRL | | LTKMGYEFGK |
| GLGRHAEGRV | | EPIHAVVLPR | | GKSLDQCVET | | LQKQTRVGKA | | GTNKPPRCRG |
| RGARPGGRPA | | PRNVFDFLNE | | KLQGQAPGAL | | EAGAAPAGRR | | SKDMYHASKS |
| AKRALSLRLF | | QTEEKIERTQ | | RDIRSIQEAL | | ARNAGRHSVA | | SAQLQEKLAG |
| AQRQLGQLRA | | QEAGLQQEQR | | KADTHKKMTE | | F |
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000197114 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027582 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ordway JM, Bedell JA, Citek RW, Nunberg A, Garrido A, Kendall R, Stevens JR, Cao D, Doerge RW, Korshunova Y, Holemon H, McPherson JD, Lakey N, Leon J, Martienssen RA, Jeddeloh JA (Nov 2006). "Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets". Carcinogenesis. 27 (12): 2409–23. doi:10.1093/carcin/bgl161. PMID 16952911.
- ^ "Entrez Gene: ZGPAT zinc finger, CCCH-type with G patch domain".
Dopunska literatura
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Rual JF, Hirozane-Kishikawa T, Hao T, et al. (2004). "Human ORFeome Version 1.1: A Platform for Reverse Proteomics". Genome Res. 14 (10B): 2128–35. doi:10.1101/gr.2973604. PMC 528929. PMID 15489335.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
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