TNN (gen)

TNN (gen)
Identifikatori
AliasiTNN
Vanjski ID-jeviOMIM: 617472 MGI: 2665790 HomoloGene: 18634 GeneCards: TNN
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za TNN (gen)
Genomska lokacija za TNN (gen)
Bend1q25.1Početak175,067,833 bp[1]
Kraj175,148,075 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za TNN (gen)
Genomska lokacija za TNN (gen)
Bend1|1 H2.1Početak159,912,599 bp[2]
Kraj159,981,150 bp[2]
Ontologija gena
Molekularna funkcija• integrin binding
• vezivanje identičnih proteina
• molekularna funkcija
Ćelijska komponenta• extracellular region
• cell surface
• ćelijska komponenta
• neuron projection
• soma
• CA3 pyramidal cell dendrite
• hippocampal mossy fiber expansion
• GO:0005578 Vanćelijski matriks
Biološki proces• cell-matrix adhesion
• axonogenesis
• osteoblast development
• negative regulation of osteoblast proliferation
• negative regulation of osteoblast differentiation
• negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation
• dendrite self-avoidance
• negative regulation of neuron migration
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

63923

329278

Ensembl

ENSG00000120332

ENSMUSG00000026725

UniProt

Q9UQP3

Q80Z71

RefSeq (mRNK)

NM_022093

NM_177839

RefSeq (bjelančevina)

NP_071376

NP_808507

Lokacija (UCSC)Chr 1: 175.07 – 175.15 MbChr 1: 159.91 – 159.98 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Tenascin N jest protein koji je kod ljudi kodiran genom TNN sa hromosoma 1.[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.299 aminokiselina, a molekulska težina 144 034 Da.[6]

1020304050
MSLQEMFRFPMGLLLGSVLLVASAPATLEPPGCSNKEQQVTVSHTYKIDV
PKSALVQVDADPQPLSDDGASLLALGEAREEQNIIFRHNIRLQTPQKDCE
LAGSVQDLLARVKKLEEEMVEMKEQCSAQRCCQGVTDLSRHCSGHGTFSL
ETCSCHCEEGREGPACERLACPGACSGHGRCVDGRCLCHEPYVGADCGYP
ACPENCSGHGECVRGVCQCHEDFMSEDCSEKRCPGDCSGHGFCDTGECYC
EEGFTGLDCAQVVTPQGLQLLKNTEDSLLVSWEPSSQVDHYLLSYYPLGK
ELSGKQIQVPKEQHSYEILGLLPGTKYIVTLRNVKNEVSSSPQHLLATTD
LAVLGTAWVTDETENSLDVEWENPSTEVDYYKLRYGPMTGQEVAEVTVPK
SSDPKSRYDITGLHPGTEYKITVVPMRGELEGKPILLNGRTEIDSPTNVV
TDRVTEDTATVSWDPVQAVIDKYVVRYTSADGDTKEMAVHKDESSTVLTG
LKPGEAYKVYVWAERGNQGSKKADTNALTEIDSPANLVTDRVTENTATIS
WDPVQATIDKYVVRYTSADDQETREVLVGKEQSSTVLTGLRPGVEYTVHV
WAQKGDRESKKADTNAPTDIDSPKNLVTDRVTENMATVSWDPVQAAIDKY
VVRYTSAGGETREVPVGKEQSSTVLTGLRPGMEYMVHVWAQKGDQESKKA
DTKAQTDIDSPQNLVTDRVTENMATVSWDPVRATIDRYVVRYTSAKDGET
REVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGAQESKKADTKAQTDIDSP
QNLVTDWVTENTATVSWDPVQATIDRYVVHYTSANGETREVPVGKEQSST
VLTGLRPGMEYTVHVWAQKGNQESKKADTKAQTEIDGPKNLVTDWVTENM
ATVSWDPVQATIDKYMVRYTSADGETREVPVGKEHSSTVLTGLRPGMEYM
VHVWAQKGAQESKKADTKAQTELDPPRNLRPSAVTQSGGILTWTPPSAQI
HGYILTYQFPDGTVKEMQLGREDQRFALQGLEQGATYPVSLVAFKGGRRS
RNVSTTLSTVGARFPHPSDCSQVQQNSNAASGLYTIYLHGDASRPLQVYC
DMETDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGLDKLHNL
TTGTPARYEVRVDLQTANESAYAIYDFFQVASSKERYKLTVGKYRGTAGD
ALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNGRYGETK
HSEGVNWEPWKGHEFSIPYVELKIRPHGYSREPVLGRKKRTLRGRLRTF

Refrerence

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120332 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026725 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "HUGO Gene Nomenclature Commitee, HGNC:22942" (jezik: engleski). Arhivirano s originala, 24. 8. 2017. Pristupljeno 12. 4. 2022.
  6. ^ "UniProt, Q9UQP3" (jezik: engleski). Pristupljeno 18. 9. 2018.

Dopunska literatura

  • NIH (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14: 2121–2127. PubMed doi:10.1101/gr.2596504

Vanjski linkovi

Portal iconPortal Biologija
Portal iconPortal Hemija