TNIP2
TNFAIP3-interaktivirajući protein 2
jest protein koji je kod ljudi kodiran genom TNIP2 sa hromosoma 4 .[ 5] [ 6] [ 7] [ 8]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 429 aminokiselina , а molekulska težina 48.700 Da .[ 9]
10 20 30 40 50 MSRDPGSGGW EEAPRAAAAL CTLYHEAGQR LRRLQDQLAA RDALIARLRA RLAALEGDAA PSLVDALLEQ VARFREQLRR QEGGAAEAQM RQEIERLTER LEEKEREMQQ LLSQPQHERE KEVVLLRRSM AEGERARAAS DVLCRSLANE THQLRRTLTA TAHMCQHLAK CLDERQHAQR NVGERSPDQS EHTDGHTSVQ SVIEKLQEEN RLLKQKVTHV EDLNAKWQRY NASRDEYVRG LHAQLRGLQI PHEPELMRKE ISRLNRQLEE KINDCAEVKQ ELAASRTARD AALERVQMLE QQILAYKDDF MSERADRERA QSRIQELEEK VASLLHQVSW RQDSREPDAG RIHAGSKTAK YLAADALELM VPGGWRPGTG SQQPEPPAEG GHPGAAQRGQ GDLQCPHCLQ CFSDEQGEEL LRHVAECCQ
Reference
^ a b c GRCh38: Ensembl release 89: ENSG00000168884 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059866 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Van Huffel S, Delaei F, Heyninck K, De Valck D, Beyaert R (Aug 2001). "Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2" . J Biol Chem . 276 (32): 30216–23. doi :10.1074/jbc.M100048200 PMID 11390377 . ^ Tadros A, Hughes DP, Dunmore BJ, Brindle NP (Dec 2003). "ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1" . Blood . 102 (13): 4407–9. doi :10.1182/blood-2003-05-1602 PMID 12933576 . ^ "Entrez Gene: TNIP2 TNFAIP3 interacting protein 2" .^ "TNIP2 (human)" . www.phosphosite.org . Pristupljeno 31. 10. 2020 .^ "UniProt, Q8NFZ5" (jezik: engleski). Pristupljeno 31. 10. 2017 .
Dopunska literatura
Heyninck K, De Valck D, Vanden Berghe W, et al. (1999). "The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN" . J. Cell Biol . 145 (7): 1471–82. doi :10.1083/jcb.145.7.1471 . hdl :1854/LU-113881 . PMC 2133159 PMID 10385526 . Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R (2001). "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions" . FEBS Lett . 498 (1): 93–7. doi :10.1016/S0014-5793(01)02504-2 PMID 11389905 . S2CID 32414520 . Wu WS, Xu ZX, Chang KS (2002). "The promyelocytic leukemia protein represses A20-mediated transcription" . J. Biol. Chem . 277 (35): 31734–9. doi :10.1074/jbc.M201648200 PMID 12080044 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Liu WK, Chien CY, Chou CK, Su JY (2003). "An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation". J. Biomed. Sci . 10 (2): 242–52. doi :10.1159/000068708 . PMID 12595760 . S2CID 202644741 . Hughes DP, Marron MB, Brindle NP (2003). "The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2" . Circ. Res . 92 (6): 630–6. doi :10.1161/01.RES.0000063422.38690.DC PMID 12609966 . Chien CY, Liu WK, Chou CK, Su JY (2003). "The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation". FEBS Lett . 543 (1–3): 55–60. doi :10.1016/S0014-5793(03)00401-0 . PMID 12753905 . S2CID 31400521 . Liu WK, Yen PF, Chien CY, et al. (2004). "The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis" . Biochem. J . 378 (Pt 3): 867–76. doi :10.1042/BJ20031736 . PMC 1224013 PMID 14653779 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol . 6 (2): 97–105. doi :10.1038/ncb1086 . PMID 14743216 . S2CID 11683986 . Lang V, Symons A, Watton SJ, et al. (2004). "ABIN-2 Forms a Ternary Complex with TPL-2 and NF-κB1 p105 and Is Essential for TPL-2 Protein Stability" . Mol. Cell. Biol . 24 (12): 5235–48. doi :10.1128/MCB.24.12.5235-5248.2004 . PMC 419892 PMID 15169888 . Li CC, Chou CK, Wang MH, Tsai TF (2006). "Overexpression of ABIN-2, a negative regulator of NF-kappaB, delays liver regeneration in the ABIN-2 transgenic mice". Biochem. Biophys. Res. Commun . 342 (1): 300–9. doi :10.1016/j.bbrc.2006.01.114 . PMID 16480954 . Greenberg H, Ye X, Wilson D, et al. (2006). "Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo". Biochem. Biophys. Res. Commun . 343 (2): 591–6. doi :10.1016/j.bbrc.2006.03.015 . PMID 16554025 . Liu Y, Nakahara T, Miyakoshi J, et al. (2007). "Nuclear accumulation and activation of nuclear factor kappaB after split-dose irradiation in LS174T cells" . J. Radiat. Res . 48 (1): 13–20. doi :10.1269/jrr.0615 PMID 17038805 .
