TMEM109

TMEM109
Identifikatori
AliasiTMEM109
Vanjski ID-jeviMGI: 1915789 HomoloGene: 11458 GeneCards: TMEM109
Lokacija gena (čovjek)
Hromosom 11 (čovjek)
Hrom.Hromosom 11 (čovjek)[1]
Hromosom 11 (čovjek)
Genomska lokacija za TMEM109
Genomska lokacija za TMEM109
Bend11q12.2Početak60,914,158 bp[1]
Kraj60,923,443 bp[1]
Lokacija gena (miš)
Hromosom 19 (miš)
Hrom.Hromosom 19 (miš)[2]
Hromosom 19 (miš)
Genomska lokacija za TMEM109
Genomska lokacija za TMEM109
Bend19|19 APočetak10,848,024 bp[2]
Kraj10,859,365 bp[2]
Ontologija gena
Molekularna funkcija• voltage-gated ion channel activity
• molekularna funkcija
• GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta• sarcoplasmic reticulum membrane
• Egzosom
• endoplasmic reticulum membrane
• jedro
• membrana
• Sarkoplazmatski retikulum
• nuclear outer membrane
• integral component of membrane
• Endoplazmatski retikulum
Biološki proces• ion transport
• negative regulation of cell death
• cellular response to gamma radiation
• intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
• regulation of ion transmembrane transport
• GO:0015915 transport
• ion transmembrane transport
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

79073

68539

Ensembl

ENSG00000110108

ENSMUSG00000034659

UniProt

Q9BVC6

Q3UBX0

RefSeq (mRNK)

NM_024092

NM_134142

RefSeq (bjelančevina)

NP_076997

NP_598903

Lokacija (UCSC)Chr 11: 60.91 – 60.92 MbChr 19: 10.85 – 10.86 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Transmembranski protein 109 je protein koji je kod ljudi kodiran genom TMEM109. [5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 243 aminokiseline, а molekulska težina 26.210 Da.[6].

1020304050
MAASSISSPWGKHVFKAILMVLVALILLHSALAQSRRDFAPPGQQKREAP
VDVLTQIGRSVRGTLDAWIGPETMHLVSESSSQVLWAISSAISVAFFALS
GIAAQLLNALGLAGDYLAQGLKLSPGQVQTFLLWGAGALVVYWLLSLLLG
LVLALLGRILWGLKLVIFLAGFVALMRSVPDPSTRALLLLALLILYALLS
RLTGSRASGAQLEAKVRGLERQVEELRWRQRRAAKGARSVEEE

Ovaj protein tvori kationski ionski kanal u membrani endoplazmatskog retikuluma, skupljajući šest identičnih podjedinica.[7]

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110108 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034659 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Transmembrane protein 109". Pristupljeno 2. 7. 2016.
  6. ^ "UniProt, Q9BVC6". Pristupljeno 28. 8. 2021.
  7. ^ Venturi, Elisa; Mio, Kazuhiro; Nishi, Miyuki; Ogura, Toshihiko; Moriya, Toshio; Pitt, Samantha J.; Okuda, Kazutaka; Kakizawa, Sho; Sitsapesan, Rebecca; Sato, Chikara; Takeshima, Hiroshi (2011). "Mitsugumin 23 Forms a Massive Bowl-Shaped Assembly and Cation-Conducting Channel". Biochemistry. 50 (13): 2623–2632. doi:10.1021/bi1019447. ISSN 0006-2960.

Dopunska literatura

  • Yamazaki T, Sasaki N, Nishi M, Takeshima H (2010). "Facilitation of DNA damage-induced apoptosis by endoplasmic reticulum protein mitsugumin23". Biochem. Biophys. Res. Commun. 392 (2): 196–200. doi:10.1016/j.bbrc.2010.01.013. PMID 20060811.