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THRSP
Identifikatori
Aliasi	THRSP
Vanjski ID-jevi	OMIM: 601926 MGI: 109126 HomoloGene: 2441 GeneCards: THRSP
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	78,068,351 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	97,066,937 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• protein homodimerization activity; • vezivanje identičnih proteina; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• citoplazma; • jedro; • nukleoplazma; • citosol;
Biološki proces	• regulation of lipid biosynthetic process; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • lipid metabolism; • regulation of triglyceride biosynthetic process; • carnitine shuttle; • response to bacterium;
	Izvori:Amigo / QuickGO
Ortolozi
	7069
	21835
	ENSG00000151365
	ENSMUSG00000035686
	Q92748
	Q62264
	NM_003251
	NM_009381
	NP_003242
	NP_033407
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Tiroidnim hormonom inducibilni jetreni protein je protein koji je kod ljudi kodiran genom THRSP.^[5]^[6]

Protein kodiran ovim genom sličan je genskom proizvodu S14, pacovskog gena, čija je ekspresija ograničena na jetru i masno tkivo i kontrolirana je nutritivnim i hormonskim faktorima.

Pokazalo se da se ovaj gen eksprimira u jetri i adipocitima, posebno u lipomskim modulima. Također je utvrđeno da se eksprimira u lipogenom raku dojke, što ukazuje na ulogu u tumorskoj kontroli metabolizma lipida.^[6]

Ranije je THRSP bio među identificiranim reguliranim genima u prefrontalnom korteksu spontano hipertenzivnih pacova (SHR/NCrl) i Wistar-Kyoto (WKY/NCrl) pacova koji su pokazivali ponašanje nepažnje.^[7] Nakon toga, prekomjerna ekspresija THRSP-a izazvala je nepažnju, ali ne i hiperaktivno i impulzivno ponašanje miševa, što ukazuje na to da ovaj gen ima ulogu u fenotipu obilježenom nepažnjom ADHD -a.^[8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 146 aminokiselina, а molekulska težina 16.561 Da.^[9].

10	20	30	40	50
MQVLTKRYPK	NCLLTVMDRY	AAEVHNMEQV	VMIPSLLRDV	QLSGPGGQAQ
AEAPDLYTYF	TMLKAICVDV	DHGLLPREEW	QAKVAGSEEN	GTAETEEVED
ESASGELDLE	AQFHLHFSSL	HHILMHLTEK	AQEVTRKYQE	MTGQVW

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151365 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035686 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Grillasca JP, Gastaldi M, Khiri H, Dace A, Peyrol N, Reynier P, Torresani J, Planells R (Feb 1997). "Cloning and initial characterization of human and mouse Spot 14 genes". FEBS Lett. 401 (1): 38–42. doi:10.1016/S0014-5793(96)01433-0. PMID 9003802. S2CID 44575293.
^ ^a ^b "Entrez Gene: THRSP thyroid hormone responsive (SPOT14 homolog, rat)".
^ dela Peña, Ike; Bang, Minji; Lee, Jinhee; de la Peña, June Bryan; Kim, Bung-Nyun; Han, Doug Hyun; Noh, Minsoo; Shin, Chan Young; Cheong, Jae Hoon (septembar 2015). "Common prefrontal cortical gene expression profiles between adolescent SHR/NCrl and WKY/NCrl rats which showed inattention behavior". Behavioural Brain Research (jezik: engleski). 291: 268–276. doi:10.1016/j.bbr.2015.05.012. PMID 26048425. S2CID 9853684.
^ Custodio, Raly James Perez; Botanas, Chrislean Jun; de la Peña, June Bryan; dela Peña, Irene Joy; Kim, Mikyung; Sayson, Leandro Val; Abiero, Arvie; Ryoo, Zae Young; Kim, Bung-Nyun; Kim, Hee Jin; Cheong, Jae Hoon (oktobar 2018). "Overexpression of the Thyroid Hormone-Responsive (THRSP) Gene in the Striatum Leads to the Development of Inattentive-like Phenotype in Mice". Neuroscience (jezik: engleski). 390: 141–150. doi:10.1016/j.neuroscience.2018.08.008. PMID 30138648. S2CID 52075574.
^ "UniProt, Q92748". Pristupljeno 27. 8. 2021.

Dopunska literatura

Cunningham BA, Moncur JT, Huntington JT, Kinlaw WB (1998). ""Spot 14" protein: a metabolic integrator in normal and neoplastic cells". Thyroid. 8 (9): 815–25. doi:10.1089/thy.1998.8.815. PMID 9777755.
Ota Y, Mariash A, Wagner JL, Mariash CN (1997). "Cloning, expression and regulation of the human S14 gene". Mol. Cell. Endocrinol. 126 (1): 75–81. doi:10.1016/S0303-7207(96)03971-8. PMID 9027365. S2CID 22056127.
Taviaux S, Planells R, Gastaldi M, et al. (1997). "Assignment of thyroid hormone responsive SPOT 14 homolog (THRSP) to human chromosome 11 bands q13.5→q14.1 by in situ hybridization". Cytogenet. Cell Genet. 76 (3–4): 219–20. doi:10.1159/000134553. PMID 9186528.
Moncur JT, Park JP, Maloney M, et al. (1997). "Assignment of the "spot 14" gene (THRSP) to human chromosome band 11q13.5 by in situ hybridization". Cytogenet. Cell Genet. 78 (2): 131–2. doi:10.1159/000134644. PMID 9371405.
Cunningham BA, Maloney M, Kinlaw WB (1997). "Spot 14 protein-protein interactions: evidence for both homo- and heterodimer formation in vivo". Endocrinology. 138 (12): 5184–8. doi:10.1210/en.138.12.5184. PMID 9389499.
Moncur JT, Park JP, Memoli VA, et al. (1998). "The "Spot 14" gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: implications for control of tumor metabolism". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6989–94. Bibcode:1998PNAS...95.6989M. doi:10.1073/pnas.95.12.6989. PMC 22712. PMID 9618526.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Campbell MC, Anderson GW, Mariash CN (2004). "Human spot 14 glucose and thyroid hormone response: characterization and thyroid hormone response element identification". Endocrinology. 144 (12): 5242–8. doi:10.1210/en.2002-0008. PMID 12960053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Chou WY, Cheng YS, Ho CL, et al. (2007). "Human spot 14 protein interacts physically and functionally with the thyroid receptor". Biochem. Biophys. Res. Commun. 357 (1): 133–8. doi:10.1016/j.bbrc.2007.03.103. PMID 17418816.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151365 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035686 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9003802-5] Grillasca JP, Gastaldi M, Khiri H, Dace A, Peyrol N, Reynier P, Torresani J, Planells R (Feb 1997). "Cloning and initial characterization of human and mouse Spot 14 genes". FEBS Lett. 401 (1): 38–42. doi:10.1016/S0014-5793(96)01433-0. PMID 9003802. S2CID 44575293.

[entrez-6] "Entrez Gene: THRSP thyroid hormone responsive (SPOT14 homolog, rat)".

[7] Peña, Ike; Bang, Minji; Lee, Jinhee; de la Peña, June Bryan; Kim, Bung-Nyun; Han, Doug Hyun; Noh, Minsoo; Shin, Chan Young; Cheong, Jae Hoon (septembar 2015). "Common prefrontal cortical gene expression profiles between adolescent SHR/NCrl and WKY/NCrl rats which showed inattention behavior". Behavioural Brain Research (jezik: engleski). 291: 268–276. doi:10.1016/j.bbr.2015.05.012. PMID 26048425. S2CID 9853684.

[8] Custodio, Raly James Perez; Botanas, Chrislean Jun; de la Peña, June Bryan; dela Peña, Irene Joy; Kim, Mikyung; Sayson, Leandro Val; Abiero, Arvie; Ryoo, Zae Young; Kim, Bung-Nyun; Kim, Hee Jin; Cheong, Jae Hoon (oktobar 2018). "Overexpression of the Thyroid Hormone-Responsive (THRSP) Gene in the Striatum Leads to the Development of Inattentive-like Phenotype in Mice". Neuroscience (jezik: engleski). 390: 141–150. doi:10.1016/j.neuroscience.2018.08.008. PMID 30138648. S2CID 52075574.

[UniProt-9] "UniProt, Q92748". Pristupljeno 27. 8. 2021.

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