PKIB
Inhibitor beta cAMP -ovisne protein-kinaze jest protein koji je kod ljudi kodiran genom PKIB .[ 5] [ 6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 78 aminokiselina , а molekulska težina 8.468 Da .[ 7]
10 20 30 40 50 MRTDSSKMTD VESGVANFAS SARAGRRNAL PDIQSSAATD GTSDLPLKLE ALSVKEDAKE KDEKTTQDQL EKPQNEEK
Funkcija
Protein kodiran ovim genom član je porodice proteina ovisnih o cikličnom adenozin-monofosfatu inhibitora protein-kinaze . Studije sličnog proteina na pacovima sugeriraju da ovaj protein može stupiti u interakciju s katalitskom podjedinicom cAMP -ovisne protein-kinaze i djelovati kao kompetitivni inhibitor . Prijavljena su najmanje tri alternativno prerađene varijante transkripta koje kodiraju isti protein.[ 6]
Reference
^ a b c GRCh38: Ensembl release 89: ENSG00000135549 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019876 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA" . Biochem J . 349 (Pt 2): 403–7. doi :10.1042/0264-6021:3490403 . PMC 1221161 PMID 10880337 . ^ a b "Entrez Gene: PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta" .^ "UniProt, Q9C010" (jezik: engleski). Pristupljeno 10. 10. 2017 .
Dopunska literatura
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11. doi :10.1038/nature02055 PMID 14574404 . Giangrande PH, Hallstrom TC, Tunyaplin C, et al. (2003). "Identification of E-Box Factor TFE3 as a Functional Partner for the E2F3 Transcription Factor" . Mol. Cell. Biol . 23 (11): 3707–20. doi :10.1128/MCB.23.11.3707-3720.2003 . PMC 155231 PMID 12748276 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Qi ZY, Li Y, Ying K, et al. (2002). "Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes". J. Neurooncol . 56 (3): 197–208. doi :10.1023/A:1015079705841 . PMID 12061725 . S2CID 23878825 . Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res . 99 (2): 145–9. doi :10.1016/S0169-328X(02)00104-3 . PMID 11978406 . Scarpetta MA, Uhler MD (1993). "Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse" . J. Biol. Chem . 268 (15): 10927–31. doi :10.1016/S0021-9258(18)82074-9 PMID 7684369 . Van Patten SM, Ng DC, Th'ng JP, et al. (1991). "Molecular cloning of a rat testis form of the inhibitor protein of cAMP-dependent protein kinase" . Proc. Natl. Acad. Sci. U.S.A . 88 (12): 5383–7. doi :10.1073/pnas.88.12.5383 PMC 51877 PMID 2052616 .
