PARVB
Beta–parvin jest protein koji je kod ljudi kodiran genom PARVB sa hromosoma 22 .[ 5] [ 6] [ 7]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 364 aminokiseline , a molekulska težina 41.714 Da .[ 7]
10 20 30 40 50 MSSAPRSPTP RPRRMKKDES FLGKLGGTLA RKRRAREVSD LQEEGKNAIN SPMSPALVDV HPEDTQLEEN EERTMIDPTS KEDPKFKELV KVLLDWINDV LVEERIIVKQ LEEDLYDGQV LQKLLEKLAG CKLNVAEVTQ SEIGQKQKLQ TVLEAVHDLL RPRGWALRWS VDSIHGKNLV AILHLLVSLA MHFRAPIRLP EHVTVQVVVV RKREGLLHSS HISEELTTTT EMMMGRFERD AFDTLFDHAP DKLSVVKKSL ITFVNKHLNK LNLEVTELET QFADGVYLVL LMGLLEDYFV PLHHFYLTPE SFDQKVHNVS FAFELMLDGG LKKPKARPED VVNLDLKSTL RVLYNLFTKY KNVE
Funkcija
Članovi porodice parvina, uključujući PARVB, PARVA i PARVG , su proteini koji vezuju aktin , povezani sa fokusnim kontaktima (prema OMIM -u).[ 7]
Reference
^ a b c GRCh38: Ensembl release 89: ENSG00000188677 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022438 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics" . Genome Res . 10 (5): 703–13. doi :10.1101/gr.10.5.703 . PMC 310876 PMID 10810093 . ^ Olski TM, Noegel AA, Korenbaum E (Feb 2001). "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily". J Cell Sci . 114 (Pt 3): 525–38. doi :10.1242/jcs.114.3.525 . PMID 11171322 . ^ a b c "Entrez Gene: PARVB parvin, beta" .
Dopunska literatura
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22" . Nature . 402 (6761): 489–95. doi :10.1038/990031 PMID 10591208 . Yamaji S, Suzuki A, Sugiyama Y, et al. (2001). "A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction" . J. Cell Biol . 153 (6): 1251–64. doi :10.1083/jcb.153.6.1251 . PMC 2192033 PMID 11402068 . Korenbaum E, Olski TM, Noegel AA (2002). "Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans". Gene . 279 (1): 69–79. doi :10.1016/S0378-1119(01)00743-0 . PMID 11722847 . Yamaji S, Suzuki A, Kanamori H, et al. (2002). "Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation". Biochem. Biophys. Res. Commun . 297 (5): 1324–31. doi :10.1016/S0006-291X(02)02381-1 . PMID 12372433 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Rosenberger G, Jantke I, Gal A, Kutsche K (2003). "Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling". Hum. Mol. Genet . 12 (2): 155–67. doi :10.1093/hmg/ddg019 . PMID 12499396 . Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22" . Genome Res . 13 (1): 27–36. doi :10.1101/gr.695703 . PMC 430954 PMID 12529303 . Mishima W, Suzuki A, Yamaji S, et al. (2004). "The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor" . Genes Cells . 9 (3): 193–204. doi :10.1111/j.1356-9597.2004.00717.x PMID 15005707 . Yamaji S, Suzuki A, Kanamori H, et al. (2004). "Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction" . J. Cell Biol . 165 (4): 539–51. doi :10.1083/jcb.200308141 . PMC 2172344 PMID 15159419 . Zhang Y, Chen K, Tu Y, Wu C (2004). "Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival" . J. Biol. Chem . 279 (40): 41695–705. doi :10.1074/jbc.M401563200 PMID 15284246 . Mongroo PS, Johnstone CN, Naruszewicz I, et al. (2004). "Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer" . Oncogene . 23 (55): 8959–70. doi :10.1038/sj.onc.1208112 PMID 15467740 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Matsuda C, Kameyama K, Tagawa K, et al. (2005). "Dysferlin interacts with affixin (beta-parvin) at the sarcolemma" . J. Neuropathol. Exp. Neurol . 64 (4): 334–40. doi :10.1093/jnen/64.4.334 PMID 15835269 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 .
