NUCKS1
NUCKS1 Identifikatori Aliasi NUCKS1 Vanjski ID-jevi OMIM : 611912 MGI : 1934811 HomoloGene : 23377 GeneCards : NUCKS1 Ontologija gena Molekularna funkcija • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor binding • chromatin binding • double-stranded DNA binding • single-stranded DNA binding • vezivanje sa RNK Ćelijska komponenta • citoplazma • jedro • Hromatin • Jedarce Biološki proces • GO:1903106 positive regulation of insulin receptor signaling pathway • transcription by RNA polymerase II • glucose homeostasis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • interstrand cross-link repair • regulation of DNA strand elongation • cellular response to X-ray • regulation of DNA replication • Konverzija gena • double-strand break repair via homologous recombination • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • replication fork processing • cellular glucose homeostasis • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • GO:1903104 regulation of insulin receptor signaling pathway Izvori:Amigo / QuickGO
Ortolozi Vrste Čovjek Miš Entrez Ensembl UniProt RefSeq (mRNK) RefSeq (bjelančevina) Lokacija (UCSC) Chr 1: 205.71 – 205.75 Mb Chr 1: 131.84 – 131.86 Mb PubMed pretraga[ 3] [ 4] Wikipodaci
Jedarni sveprisutni ciklin-ovisni supstrat kazein –kinaze jest protein koji je kod ljudi kodiran genom NUCKS1 sa hromosoma 1 .[ 5] [ 6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 243 aminokiseline , a molekulska težina 27.296 Da .[ 7]
10 20 30 40 50 MSRPVRNRKV VDYSQFQESD DADEDYGRDS GPPTKKIRSS PREAKNKRRS GKNSQEDSED SEDKDVKTKK DDSHSAEDSE DEKEDHKNVR QQRQAASKAA SKQREMLMED VGSEEEQEEE DEAPFQEKDS GSDEDFLMED DDDSDYGSSK KKNKKMVKKS KPERKEKKMP KPRLKATVTP SPVKGKGKVG RPTASKASKE KTPSPKEEDE EPESPPEKKT STSPPPEKSG DEGSEDEAPS GED
Reference
^ a b c GRCh38: Ensembl release 89: ENSG00000069275 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026434 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ostvold AC, Norum JH, Mathiesen S, Wanvik B, Sefland I, Grundt K (Apr 2001). "Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo" . Eur J Biochem . 268 (8): 2430–40. doi :10.1046/j.1432-1327.2001.02120.x PMID 11298763 . ^ "Entrez Gene: NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1" .^ "UniProt, Q9H1E3" (jezik: engleski). Pristupljeno 15. 12. 2021 .
Dopunska literatura
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Thompson HG, Harris JW, Wold BJ, et al. (2003). "Identification and confirmation of a module of coexpressed genes" . Genome Res . 12 (10): 1517–22. doi :10.1101/gr.418402 . PMC 187523 PMID 12368243 . Grundt K, Skjeldal L, Anthonsen HW, et al. (2002). "A putative DNA-binding domain in the NUCKS protein". Arch. Biochem. Biophys . 407 (2): 168–75. doi :10.1016/S0003-9861(02)00513-1 . PMID 12413487 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain" . Mol. Cell. Proteomics . 3 (11): 1093–101. doi :10.1074/mcp.M400085-MCP200 PMID 15345747 . Grundt K, Haga IV, Aleporou-Marinou V, et al. (2004). "Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species". Biochem. Biophys. Res. Commun . 323 (3): 796–801. doi :10.1016/j.bbrc.2004.08.153 . PMID 15381070 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Gevaert K, Staes A, Van Damme J, et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics . 5 (14): 3589–99. doi :10.1002/pmic.200401217 . PMID 16097034 . S2CID 895879 . Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization" . Nat. Biotechnol . 24 (10): 1285–92. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Grundt K, Haga IV, Huitfeldt HS, Ostvold AC (2007). "Identification and characterization of two putative nuclear localization signals (NLS) in the DNA-binding protein NUCKS" . Biochim. Biophys. Acta . 1773 (9): 1398–406. doi :10.1016/j.bbamcr.2007.05.013 PMID 17604136 .
