NREP

NREP

Identifikatori

Vanjski ID-jevi

OMIM: 607332 MGI: 99444 HomoloGene: 70874 GeneCards: NREP

Lokacija gena (čovjek)

Hrom.	Hromosom 5 (čovjek)^[1]

Bend	5q22.1	Početak	111,662,621 bp^[1]
Bend	5q22.1	Kraj	111,997,464 bp^[1]

Lokacija gena (miš)

Hrom.	Hromosom 18 (miš)^[2]

Bend	18\|18 B1	Početak	33,570,072 bp^[2]
Bend	18\|18 B1	Kraj	33,597,082 bp^[2]

Obrazac RNK ekspresije

Više referentnih podataka o ekspresiji

Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta	• citoplazma • jedro
Biološki proces	• regulation of neuron differentiation • axon regeneration • regulation of transforming growth factor beta receptor signaling pathway
Izvori:Amigo / QuickGO

Vrste

Čovjek

Miš


9315


27528


ENSG00000134986


ENSMUSG00000042834


Q16612


Q07475

RefSeq (mRNK)

NM_001142474 NM_001142475 NM_001142476 NM_001142477 NM_001142478
NM_001142479 NM_001142480 NM_001142481 NM_001142482 NM_001142483 NM_004772


NM_001109988 NM_001109989 NM_001267717 NM_053078

RefSeq (bjelančevina)

NP_001135946 NP_001135947 NP_001135948 NP_001135949 NP_001135950
NP_001135951 NP_001135952 NP_001135953 NP_001135954 NP_001135955 NP_004763


NP_001103458 NP_001103459 NP_001254646 NP_444308

Lokacija (UCSC)

Chr 5: 111.66 – 112 Mb

Chr 18: 33.57 – 33.6 Mb

PubMed pretraga

^[3]

^[4]

Pogledaj/uredi – čovjek

Pogledaj/uredi – miš

Neuronski protein 3.1 jest protein koji je kod ljudi kodiran genom NREP.^[5]^[6]^[7] Visoko je eksprimiran u mozgu.^[8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 68 aminokiselina, а molekulska težina 7.909 Da.^[9]

D: Asparaginska kiselina

E: Glutaminska kiselina

Y: Tirozin

10		20		30		40		50
MVYYPELFVW		VSQEPFPNKD		MEGRLPKGRL		PVPKEVNRKK		NDETNAASLT
PLGSSELRSP		RISYLHFF

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134986 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042834 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Studler JM, Glowinski J, Lévi-Strauss M (Jun 1993). "An abundant mRNA of the embryonic brain persists at a high level in cerebellum, hippocampus and olfactory bulb during adulthood". The European Journal of Neuroscience. 5 (6): 614–23. doi:10.1111/j.1460-9568.1993.tb00527.x. PMID 8261136. S2CID 35425949.
^ Miura N, Naganuma A (Aug 2000). "Metallothionein mediates gene expression of 3.1 mRNA (PTZ17) related to epileptic seizure". FEBS Letters. 479 (3): 146–8. doi:10.1016/S0014-5793(00)01899-8. PMID 10981724. S2CID 9344664.
^ "Entrez Gene: C5orf13 chromosome 5 open reading frame 13".
^ "Human Gene NREP (ENST00000447165.6) Description and Page Index". genome.ucsc.edu.
^ "UniProt, Q16612" (jezik: engleski). Pristupljeno 13. 10. 2021.

Dopunska literatura

Taylor GA, Hudson E, Resau JH, Vande Woude GF (Feb 2000). "Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system". The Journal of Biological Chemistry. 275 (6): 4215–9. doi:10.1074/jbc.275.6.4215. PMID 10660586.
Pan D, Zhe X, Jakkaraju S, Taylor GA, Schuger L (Nov 2002). "P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype". The Journal of Clinical Investigation. 110 (9): 1349–58. doi:10.1172/JCI15614. PMC 151607. PMID 12417574.
McDonough WS, Tran NL, Berens ME (Sep 2005). "Regulation of glioma cell migration by serine-phosphorylated P311". Neoplasia. 7 (9): 862–72. doi:10.1593/neo.05190. PMC 1501936. PMID 16229809.
Zhao L, Leung JK, Yamamoto H, Goswami S, Kheradmand F, Vu TH (Jul 2006). "Identification of P311 as a potential gene regulating alveolar generation". American Journal of Respiratory Cell and Molecular Biology. 35 (1): 48–54. doi:10.1165/rcmb.2005-0475OC. PMC 2658697. PMID 16484684.

Vanjski linkovi

Lokacija ljudskog genoma NREP i stranica sa detaljima o genu NREP u UCSC Genome Browseru.