MAML3
Upravljački protein 3 (Drosophila protein koji je kod ljudi kodiran genom MAML3 sa hromosoma 4 .[ 5]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 1.138 aminokiselina , a molekulska težina 122.293 Da .[ 6]
10 20 30 40 50 MGDFAAPAAA ANGSSICINS SLNSSLGGAG IGVNNTPNST PAAPSSNHPA AGGCGGSGGP GGGSAAVPKH STVVERLRQR IEGCRRHHVN CENRYQQAQV EQLELERRDT VSLYQRTLEQ RAKKSGAGTG KQQHPSKPQQ DAEAASAEQR NHTLIMLQET VKRKLEGARS PLNGDQQNGA CDGNFSPTSK RIRKDISAGM EAINNLPSNM PLPSASPLHQ LDLKPSLPLQ NSGTHTPGLL EDLSKNGRLP EIKLPVNGCS DLEDSFTILQ SKDLKQEPLD DPTCIDTSET SLSNQNKLFS DINLNDQEWQ ELIDELANTV PEDDIQDLFN EDFEEKKEPE FSQPATETPL SQESASVKSD PSHSPFAHVS MGSPQARPSS SGPPFSTVST ATSLPSVAST PAAPNPASSP ANCAVQSPQT PNQAHTPGQA PPRPGNGYLL NPAAVTVAGS ASGPVAVPSS DMSPAEQLKQ MAAQQQQRAK LMQQKQQQQQ QQQQQQQQQQ QQQQQQQQQQ HSNQTSNWSP LGPPSSPYGA AFTAEKPNSP MMYPQAFNNQ NPIVPPMANN LQKTTMNNYL PQNHMNMINQ QPNNLGTNSL NKQHNILTYG NTKPLTHFNA DLSQRMTPPV ANPNKNPLMP YIQQQQQQQQ QQQQQQQQQQ PPPPQLQAPR AHLSEDQKRL LLMKQKGVMN QPMAYAALPS HGQEQHPVGL PRTTGPMQSS VPPGSGGMVS GASPAGPGFL GSQPQAAIMK QMLIDQRAQL IEQQKQQFLR EQRQQQQQQQ QQILAEQQLQ QSHLPRQHLQ PQRNPYPVQQ VNQFQGSPQD IAAVRSQAAL QSMRTSRLMA QNAGMMGIGP SQNPGTMATA AAQSEMGLAP YSTTPTSQPG MYNMSTGMTQ MLQHPNQSGM SITHNQAQGP RQPASGQGVG MVSGFGQSML VNSAITQQHP QMKGPVGQAL PRPQAPPRLQ SLMGTVQQGA QSWQQRSLQG MPGRTSGELG PFNNGASYPL QAGQPRLTKQ HFPQGLSQSV VDANTGTVRT LNPAAMGRQM MPSLPGQQGT SQARPMVMSG LSQGVPGMPA FSQPPAQQQI PSGSFAPSSQ SQAYERNAPQ DVSYNYSGDG AGGSFPGLPD GADLVDSIIK GGPGDEWMQE LDELFGNP
Reference
Dopunska literatura
Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (juli 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics . 100 (1): 114–22. doi :10.1007/s004390050476 . PMID 9225980 . S2CID 25999127 . Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M (decembar 2002). "Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling" . The Journal of Biological Chemistry . 277 (52): 50612–20. doi :10.1074/jbc.M209529200 PMID 12386158 . Hu Z, Shi Y, Mo X, Xu J, Zhao B, Lin Y, Yang S, Xu Z, Dai J, Pan S, Da M, Wang X, Qian B, Wen Y, Wen J, Xing J, Guo X, Xia Y, Ma H, Jin G, Yu S, Liu J, Zhou Z, Wang X, Chen Y, Sha J, Shen H (juli 2013). "A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations". Nature Genetics . 45 (7): 818–21. doi :10.1038/ng.2636 . PMID 23708190 . S2CID 7904277 . Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (februar 2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway" . Nature Genetics . 33 (2): 208–13. doi :10.1038/ng1083 . PMID 12539049 . S2CID 23417795 . Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (novembar 2002). "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors" . Molecular and Cellular Biology . 22 (21): 7688–700. doi :10.1128/MCB.22.21.7688-7700.2002 . PMC 135662 PMID 12370315 .
