IK (gen)
Protein Red jest protein koji je kod ljudi kodiran genom IK sa hromosoma 5 .[ 5] [ 6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 557 aminokiselina , а molekulska težina 65.602 Da .[ 7]
10 20 30 40 50 MPERDSEPFS NPLAPDGHDV DDPHSFHQSK LTNEDFRKLL MTPRAAPTSA PPSKSRHHEM PREYNEDEDP AARRRKKKSY YAKLRQQEIE RERELAEKYR DRAKERRDGV NKDYEETELI STTANYRAVG PTAEADKSAA EKRRQLIQES KFLGGDMEHT HLVKGLDFAL LQKVRAEIAS KEKEEEELME KPQKETKKDE DPENKIEFKT RLGRNVYRML FKSKAYERNE LFLPGRMAYV VDLDDEYADT DIPTTLIRSK ADCPTMEAQT TLTTNDIVIS KLTQILSYLR QGTRNKKLKK KDKGKLEEKK PPEADMNIFE DIGDYVPSTT KTPRDKERER YRERERDRER DRDRDRERER ERDRERERER DREREEEKKR HSYFEKPKVD DEPMDVDKGP GSTKELIKSI NEKFAGSAGW EGTESLKKPE DKKQLGDFFG MSNSYAECYP ATMDDMAVDS DEEVDYSKMD QGNKKGPLGR WDFDTQEEYS EYMNNKEALP KAAFQYGIKM SEGRKTRRFK ETNDKAELDR QWKKISAIIE KRKKMEADGV EVKRPKY
Funkcija
Protein kodiran ovim genom identificiran je njegovim RED ponavljanjem, nizom ponovljenih ostataka arginina , glutaminske kiseline i asparaginske kiseline . Protein se nalazi u diskretnim tačkicama unutar jedra , isključujući nukleolus . Njegova funkcija nije poznata. Ovaj gen se mapira na hromosomu 5 ; međutim, njegov pseudogen može biti i na hromosomu 2 .[ 6]
Reference
^ a b c GRCh38: Ensembl release 89: ENSG00000113141 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024474 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Krief P, Augery-Bourget Y, Plaisance S, Merck MF, Assier E, Tanchou V, Billard M, Boucheix C, Jasmin C, Azzarone B (Dec 1994). "A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization" . Oncogene . 9 (12): 3449–56. PMID 7970704 . ^ a b "Entrez Gene: IK IK cytokine, down-regulator of HLA II" .^ "UniProt, Q13123" (jezik: engleski). Pristupljeno 16. 10. 2021 .
Dopunska literatura
Cao LX, Le Bousse-Kerdiles MC, Clay D, et al. (1997). "Implication of a new molecule IK in CD34+ hematopoietic progenitor cell proliferation and differentiation" . Blood . 89 (10): 3615–23. doi :10.1182/blood.V89.10.3615 PMID 9160666 . Assier E, Bouzinba-Segard H, Stolzenberg MC, et al. (1999). "Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat". Gene . 230 (2): 145–54. doi :10.1016/S0378-1119(99)00066-9 . PMID 10216252 . Willers J, Häffner A, Zepter K, et al. (2001). "The interferon inhibiting cytokine IK is overexpressed in cutaneous T cell lymphoma derived tumor cells that fail to upregulate major histocompatibility complex class II upon interferon-gamma stimulation" . J. Invest. Dermatol . 116 (6): 874–9. doi :10.1046/j.1523-1747.2001.01339.x PMID 11407974 .
