GFPT1
Izomerirajuća glukozamin—fruktoza-6-fosfat aminotransferaza 1 jest enzim koji je kod ljudi kodiran genom GFPT1 sa hromosoma 2 .[ 5] [ 6]
Amiokiselininska sekvenca
Dužina polipeptidnog lanca je 699 aminokiselina , a molkekulska iežina 78.806 Da .[ 7]
10 20 30 40 50 MCGIFAYLNY HVPRTRREIL ETLIKGLQRL EYRGYDSAGV GFDGGNDKDW EANACKIQLI KKKGKVKALD EEVHKQQDMD LDIEFDVHLG IAHTRWATHG EPSPVNSHPQ RSDKNNEFIV IHNGIITNYK DLKKFLESKG YDFESETDTE TIAKLVKYMY DNRESQDTSF TTLVERVIQQ LEGAFALVFK SVHFPGQAVG TRRGSPLLIG VRSEHKLSTD HIPILYRTAR TQIGSKFTRW GSQGERGKDK KGSCNLSRVD STTCLFPVEE KAVEYYFASD ASAVIEHTNR VIFLEDDDVA AVVDGRLSIH RIKRTAGDHP GRAVQTLQME LQQIMKGNFS SFMQKEIFEQ PESVVNTMRG RVNFDDYTVN LGGLKDHIKE IQRCRRLILI ACGTSYHAGV ATRQVLEELT ELPVMVELAS DFLDRNTPVF RDDVCFFLSQ SGETADTLMG LRYCKERGAL TVGITNTVGS SISRETDCGV HINAGPEIGV ASTKAYTSQF VSLVMFALMM CDDRISMQER RKEIMLGLKR LPDLIKEVLS MDDEIQKLAT ELYHQKSVLI MGRGYHYATC LEGALKIKEI TYMHSEGILA GELKHGPLAL VDKLMPVIMI IMRDHTYAKC QNALQQVVAR QGRPVVICDK EDTETIKNTK RTIKVPHSVD CLQGILSVIP LQLLAFHLAV LRGYDVDFPR NLAKSVTVE
Funkcija
Glutamin -fruktoza -6-fosfat transaminaza 1 je prvi enzim koji ograničava brzinu heksozaminskog puta. GFAT kontrolira protok glukoze u heksozaminskom putu i katalizira stvaranje glukozamin 6-fosfata.[ 6]
Reference
^ a b c GRCh38: Ensembl release 89: ENSG00000198380 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029992 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ McKnight GL, Mudri SL, Mathewes SL, Traxinger RR, Marshall S, Sheppard PO, O'Hara PJ (Jan 1993). "Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase" . J Biol Chem . 267 (35): 25208–12. doi :10.1016/S0021-9258(19)74026-5 PMID 1460020 . ^ a b "Entrez Gene: GFPT1 glutamine-fructose-6-phosphate transaminase 1" .^ "UniProt, Q06210" (jezik: engleski). Pristupljeno 12. 11. 2021 .
Dopunska literatura
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Vanjski linkovi
