C1QTNF4

C1QTNF4
Identifikatori
AliasiC1QTNF4
Vanjski ID-jeviOMIM: 614911 MGI: 1914695 HomoloGene: 12134 GeneCards: C1QTNF4
Lokacija gena (čovjek)
Hromosom 11 (čovjek)
Hrom.Hromosom 11 (čovjek)[1]
Hromosom 11 (čovjek)
Genomska lokacija za C1QTNF4
Genomska lokacija za C1QTNF4
Bend11p11.2Početak47,589,667 bp[1]
Kraj47,594,411 bp[1]
Lokacija gena (miš)
Hromosom 2 (miš)
Hrom.Hromosom 2 (miš)[2]
Hromosom 2 (miš)
Genomska lokacija za C1QTNF4
Genomska lokacija za C1QTNF4
Bend2|2 E1Početak90,716,204 bp[2]
Kraj90,720,869 bp[2]
Ontologija gena
Molekularna funkcija• cytokine activity
• molekularna funkcija
Ćelijska komponenta• extracellular region
• Vanćelijsko
Biološki proces• regulation of signaling receptor activity
• positive regulation of interleukin-6 production
• positive regulation of interleukin-6-mediated signaling pathway
• positive regulation of NIK/NF-kappaB signaling
• GO:0072468 Transdukcija signala
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

114900

67445

Ensembl

ENSG00000172247
ENSG00000284838

ENSMUSG00000040794

UniProt

Q9BXJ3

Q8R066

RefSeq (mRNK)

NM_031909

NM_026161

RefSeq (bjelančevina)

NP_114115

NP_080437

Lokacija (UCSC)Chr 11: 47.59 – 47.59 MbChr 2: 90.72 – 90.72 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein 4 srodan C1q i tumorskom faktoru nekroze je protein koji je kod ljudi kodiran genom C1QTNF4. [5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 329 aminokiselina, a molekulska težina 35.256 Da.[6].

1020304050
MLPLLLGLLGPAACWALGPTPGPGSSELRSAFSAARTTPLEGTSEMAVTF
DKVYVNIGGDFDVATGQFRCRVPGAYFFSFTAGKAPHKSLSVMLVRNRDE
VQALAFDEQRRPGARRAASQSAMLQLDYGDTVWLRLHGAPQYALGAPGAT
FSGYLVYADADADAPARGPPAPPEPRSAFSAARTRSLVGSDAGPGPRHQP
LAFDTEFVNIGGDFDAAAGVFRCRLPGAYFFSFTLGKLPRKTLSVKLMKN
RDEVQAMIYDDGASRRREMQSQSVMLALRRGDAVWLLSHDHDGYGAYSNH
GKYITFSGFLVYPDLAPAAPPGLGASELL

Reference

  1. ^ a b c ENSG00000284838 GRCh38: Ensembl release 89: ENSG00000172247, ENSG00000284838 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040794 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: C1q and tumor necrosis factor related protein 4". Pristupljeno 1. 12. 2016.
  6. ^ "UniProt, Q9BXJ3". Pristupljeno 19. 8. 2021.

Dopunska literatura

  • Li Q, Wang L, Tan W, Peng Z, Luo Y, Zhang Y, Zhang G, Na D, Jin P, Shi T, Ma D, Wang L (2011). "Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-κB pathways and promotes cell survival in human cancer cells". Cancer Lett. 308 (2): 203–14. doi:10.1016/j.canlet.2011.05.005. PMID 21658842.