DrugBank

DrugBank, на разположение в Университета на Алберта, е биоинформатичен и химикоинформатичен ресурс, който съчетава подробна информация за медикаменти (т.е. химични, фармакологични и фармацевтични) с информация за таргетната на молекула (т.е. последователност, структура, път)​​.[1][2] Базата съдържа данни за почти 4800 вещества, включително:

  • повече от 1480, одобрени от FDA (Food and Drug Administration) молекули
  • 128 одобрени от FDA биотехнологични лекарства (протеин/пептид)
  • повече от 71 хранителни добавки
  • повече от 3200 експериментални лекарства[3]
  • повече от 2500 протеина (т.е. наркотици цел, без излишни) последователности са свързани с тези наркотици вписвания.[3]

Всеки запис в DrugCard съдържа 148 полета с данни с половината от информацията, която е посветена на моекулите/химически данни и другата половина, посветена на молекулите-мишени.[2]

Тя се поддържа от Дейвид Уишарт и Крейг Нокс.[1]

Източници

  1. ↑ а б Wishart DS, Knox C, Guo AC, et al. DrugBank: a knowledgebase for drugs, drug actions and drug targets // Nucleic Acids Research 36 (Database issue). 2008. DOI:10.1093/nar/gkm958. с. D901–6.
  2. ↑ а б Knox, C и др. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. // Nucleic acids research 39 (Database issue). 2011 Jan. с. D1035-41.
  3. ↑ а б Wishart DS, Knox C, Guo AC, et al. DrugBank: a comprehensive resource for in silico drug discovery and exploration // Nucleic Acids Research 34 (Database issue). 2006. DOI:10.1093/nar/gkj067. с. D668–D672.

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