Hussain did theatre for a few years and then came to Mumbai to work in television and films. He started out with serials like Firdaus, Kitty Party and Gaatha, and this earned him recognition.[2]Sriram Raghavan's 2004 film Ek Hasina Thi was his first film as actor. Hussain's role in the film was limited to two scenes, but he managed to impress director Ramgopal Varma, who then offered him the role of Rashid in Sarkar.[1] This role of a cold-blooded villain was much appreciated and Hussain received the "New Menace" award at the 2006 Stardust Film Awards.[3]
After Sarkar, Varma cast Hussain in almost every production of his. Hussain's second noteworthy performance was his role of Shardul in another Raghavan film – Johnny Gaddaar. This performance was so well received by audiences that people on the streets started addressing Hussain as Shardul. This was the film that brought him both decent pay cheques as well as fame.[1]
Hussain is also a talented musician – a percussionist as well as singer.[1] However, he is not to be confused with the famous tabla virtuoso Zakir Hussain (1951-2024), who starred in the film Heat and Dust.