Ayala's first professionally published comic was DC's New Talent Showcase in 2017.[1] This was the final project for DC's Talent Participation Program led by a number of DC comics talent, like Scott Snyder.[2] Ayala then wrote stories for Batgirl, the Suicide Squad, and Batman Beyond.
In 2018, they announced their first indie comic, Submerged, from Vault Comics, a retelling of the Orpheus and Eurydice myth.[3][4] In August, they were announced as the writer for the upcoming book Livewire from Valiant Entertainment,[5] about the character of Amanda McKee/Livewire. "Amanda is a warrior, but a warrior with a cause. She doesn’t think that people are expendable, but she will do whatever it takes to make sure that the Greater Good (as she sees it) is served. I think she tends to be very much a 'needs of the many' and 'by any means necessary' sort of person, with very few exceptions. But she is growing and learning, and that process of change is what I want to focus on in this first arc of the book." In 2019, they became the writer for Dynamite'sXena: Warrior Princess comic.[6]
In 2019, they were announced as the writer, alongside artist Germán Peralta, for Age of X-Man: Prisoner X.[7] "To me, Bishop is the perfect mix of historian/detective and action hero, and I wanted to reflect that in the shape of the story." They then became the writer for the new Morbius[8][9][10] ongoing and Nebula mini-seires.[11][12][13] Both books were impacted by the COVID-19 pandemic and eventually canceled.[14] They were then announced, with artist Rod Reis, as the new creative team for New Mutants during the Dawn of X.[15][16] "They are kind of the circle of the Venn diagram of my interests, storywise: headstrong teens/young adults, the potential for horror/heavy stories, found family dynamics, and a true variety of characters (in terms of gender, ethnicity, orientation, etc.)."[17] They were also announced as the writer for the Children of the Atom mini-series.[18][19][20]
Outside of Marvel, in 2019, they were announced as co-writing along with writer Danny Lore the new relaunch of James Bond for Dynamite Entertainment.[21][22] The two then also published the comic Quarter Killer through ComiXology Originals.[23][24] Ayala wrote the "Batgirls" backups for Future State: The Next Batman[25] and, in 2021, became the writer for Static: Season One for the new Milestone Media.[26] "One of the things that I've always really liked about Virgil that I hoped to replicate in a more contemporary way was that he's a weirdo. He's a weird, smart Black kid who plays Dungeons & Dragons with his friends. And he's kind of a fanboy." In 2023, a sequel, Static: Shadows of Dakota, was released.[27][28]
In 2021, they became the co-writer along with Stephanie Williams for Nubia and the Amazons, a companion book to Wonder Woman and prelude to Trial of the Amazons.[29] This book introduced marked the first appearance of a transAmazon.[30][31][32][33] Following Trial of the Amazons, Ayala co-wrote the Nubia: Coronation Special and wrote the one-shot Artemis: Wanted.[34] In addition, Ayala wrote a six-part Batman/Zatanna story for Batman: Urban Legends #11-16.[35]
