The original structure was designed in early 1615 by the Italian soldier, architect and military engineer, Ascanio Vitozzi. When he died in 1615, the project passed to his collaborators, father and son Carlo and Amedeo di Castellamonte. The original building was built for the Prince-Cardinal Maurice of Savoy during the reign of his brother Victor Amadeus I, Duke of Savoy. The property was built as a private villa with its own vineyard, hence its alternative name of Vigna di Madama. In 1637 Cardinal Maurice lost his brother and his sister-in-law Christine Marie of France became Regent of Savoy for her young son, Carlo Emanuele II of Savoy.
She used the Vigna when she could. Most of the present décor of the Vigna is from her lifetime. Her husband was the King of Sicily from 1713 until 1720 when he exchanged Sicily with Sardinia. From then on, the building was known as Villa della Regina ("Villa of the Queen"). It was here Anne Marie died in 1728. Anne Marie's eldest daughter Maria Adelaide[3] came here and tried to recreate it at Versailles at the Ménagerie.
Polyxena of Hesse-Rotenburg, daughter-in-law of Anne Marie, did some work in the main saloon of the building when she became the owner of the villa in 1728 at the death of Anne Marie.
Inside there are frescoes and paintings by Giovanni Battista Crosato, Daniel Seyter and Corrado Giaquinto in the main room, grotesques of Filippo Minei and paintings by the brothers Domenico and Giuseppe Valeriani in the near rooms; there are also precious Chinese Cabinets in lacquer and golden wood. In the park there is the Pavilion of the Solinghi, a pagoda building in which the Academy of the Solinghi used to meet; it was a group of intellectuals founded by the Cardinal Maurice.
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