Uxeau is located in the southwest of Saône-et-Loire at 150 km from Dijon and in the middle between Dijon and Clermont-Ferrand. Uxeau is located in the canton of Gueugnon, a small industrial town. Many of the inhabitants of Uxeau work or have worked at the steel works of Aperam in Gueugnon.
The summit of the Mont Dardon is in the commune of Uxeau. The Mont Dardon is located in the communes of Uxeau, Sainte-Radegonde and Issy-l'Évêque.