This was the first event to feature Venum as the new UFC's official uniform partner. The promotion had previously been partnered with Reebok since 2014, before signing a deal with Venum in July 2020 that would be made effective April 2021.[3][4]
A middleweight bout between former UFC Welterweight Championship challenger Darren Till and Marvin Vettori was expected to serve as the event headliner.[5] However, Till withdrew from the fight on March 30 due to a broken collarbone.[6] It was announced on April 1 that Kevin Holland would step in on 9 days notice to face Vettori. By making his second main event appearance in three weeks, Holland tied the record for shortest turnaround between two main events.[7]
A middleweight bout between Zak Cummings and Sam Alvey was expected to take place at the event.[8] However, Cummings withdrew from the bout on March 11 due to undisclosed reasons and was replaced by Julian Marquez.[9]
A light heavyweight bout between Shamil Gamzatov and Da Un Jung was scheduled for the preliminary portion of the card.[10] However, Gamzatov was removed from the bout on March 24 due to alleged visa issues and replaced by William Knight.[11]
Bea Malecki was expected to face Norma Dumont in a women's bantamweight bout at this event.[12] However, Malecki pulled out a week before the contest due to undisclosed reasons and was replaced by promotional newcomer Erin Blanchfield.[13]
A middleweight bout between Kyle Daukaus and Aliaskhab Khizriev was expected to take place at the event.[14] However, the bout was pulled from the card on April 7 due to COVID-19 protocols.[15]
At the weigh-ins, Ignacio Bahamondes and Norma Dumont missed weight for the respective bouts. Bahamondes weighed in at 156.75 pounds, three quarters of a pound over the lightweight non-title fight limit. His bout proceeded at a catchweight and he was fined 20% of his individual purse, which went to his opponent John Makdessi.[16] Dumont weighed in at 139.5 pounds, three and a half pounds over the women's bantamweight non-title fight limit. Her bout with Blanchfield was cancelled by the Nevada State Athletic Commission.[17]