US 67 enters Texas from Mexico as Federal Highway 16 west of Presidio. US 67 travels miles between Chinati Mountains State Natural Area and Big Bend Ranch State Park. US 67 shares an overlap with US 90 from Marfa to Alpine. Leaving US 90, US 67 travels north towards I-10. US 67 shares an overlap with I-10 for almost 25 miles. In Fort Stockton, US 385 joins this overlap. US 67/385 leave I-10 just east of Fort Stockton.
US 67 leaves I-10 with US 385 and the two share an overlap until McCamey. US 67 travels in a mostly east–west direction towards San Angelo. US 67 travels through mostly rural areas, passing through or near the towns of Rankin, Big Lake, and Mertzon. In San Angelo, parts of US 67 are known as the Houston Harte Expressway, named after the San Angelo-native publishing magnate. US 67 starts a short overlap with US 277 in San Angelo along the Houston Harte.
US 67 ends its overlap with US 277 northeast of San Angelo. US 67 travels towards Ballinger and has an overlap with US 83. Between the towns of Santa Anna and Stephenville, US 67 shares overlaps with US highways 84, 183, and 377. The overlap with US 377 starts in Brownwood and ends in south east Stephenville.
US 67 leaves Stephenville and travels to Glen Rose, the location of Dinosaur Valley State Park. US 67 then travels to Cleburne, bypassing the town on a four lane freeway; the bypass is known as Walter P. Holliday Drive from US 67 Business near Lake Pat Cleburne to FM 4, while the remainder is known as Catherine P. Raines Drive. US 67 travels through the towns of Keene, Alvarado, and Venus before entering Midlothian, where a freeway begins that travels all the way to I-35E in Dallas. US 67 shares an unsigned overlap with I-35E/US 77 to Downtown Dallas, where US 67 leaves I-35E and joins I-30.
US 67 shares an unsigned overlap with I-30 that starts in Downtown Dallas. The two highways travel through east Dallas, Mesquite, and Garland, Texas before crossing over Lake Ray Hubbard, twice. After the second crossing, the highways enter Rockwall. In Royse City, US 67 signage begins. The highways then arrive in Greenville.
US 67 has business routes in Presidio, two in San Angelo, Cleburne, Alvarado, and Sulphur Springs. An additional business route has been proposed for Dublin, and Midlothian and Greenville formerly had business routes. These routes largely follow former alignments through these cities before US 67 bypasses were constructed.