Unlike O'Donnell's daytime show, on which audience members opened the shows by announcing the day's guests, announcer Chip Zien would begin each episode by saying, "Live from New York, it's The Caroline Rhea Show! On today's show: [names of guests]...Here's Caroline!" The first five words, "Live from New York, it's," mimicked the opening tagline to Saturday Night Live, produced in the neighboring Studio 8-H. The show's intro song was Neil Diamond's "Sweet Caroline,"[2] and the audience would often sing along, vocalizing the three notes after the song's eponymous chorus and chanting "so good, so good" in response to "good times never seemed so good."
Some stations that aired Rosie also aired Caroline Rhea, but some (like WABC-TV in New York, which gave the former Rosie spot to The Wayne Brady Show) aired the show in an undesirable late-night time slot.
Most television markets that had aired the show replaced it with The Ellen DeGeneres Show, which was offered by the syndicator of both Rhea's and O'Donnell's show, Warner Bros. Television's Telepictures division. New York station WLNY-TV, which was a secondary carrier of both series, added Ellen while WABC did not; it was instead given to WNBC.