Technetium (99mTc) votumumab

Technetium (99mTc) votumumab
Monoclonal antibody
TypeWhole antibody
SourceHuman
Targettumor antigen CTAA16.88
Clinical data
ATC code
Legal status
Legal status
  • not marketed
Identifiers
CAS Number
ChemSpider
  • none
UNII
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Technetium (99mTc) votumumab (trade name HumaSPECT) is a human monoclonal antibody labelled with the radionuclide technetium-99m.[1][2] It was developed for the detection of colorectal tumors, but has never been marketed.[3]

The target of votumumab is CTAA16.88, a complex of cytokeratin polypeptides in the molecular weight range of 35 to 43 kDa, which is expressed in colorectal tumors.[4]

References

  1. ^ "International Nonproprietary Names for Pharmaceutical Substances (INN)" (PDF). WHO Drug Information. 13 (1). 1999.
  2. ^ Hendriks BS, Gaddy DF (2017). "Radiolabeled Antibody-Based Imaging in Clinical Oncology". In Olivier Jr KJ, Hurvitz SA (eds.). Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer. Hoboken, New Jersey: John Wiley & Sons. p. 441. ISBN 978-1-119-06084-0.
  3. ^ "Public Statement on HumaSPECT" (PDF). European Medicines Agency (EMA_. 23 February 2004. Archived from the original (PDF) on 2007-06-10. Non-renewal of the marketing authorisation in the European Union
  4. ^ "Summary of Product Characteristics for HumaSPECT" (PDF). European Medicines Agency (EMA).


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