Fallypride

Fallypride (18F)
Clinical data
Pregnancy
category
  • N/A
ATC code
  • none
Legal status
Legal status
  • Research compound
Identifiers
  • 5-(3-18F-fluoropropyl)-2,3-dimethoxy-N-[(2S)-1-prop-2-enylpyrrolidin-2-yl]methyl]benzamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H29FN2O3
Molar mass364.461 g·mol−1
3D model (JSmol)
  • COC1=CC(=CC(=C1OC)C(=O)NC[C@@H]2CCCN2CC=C)CCCF
  • InChI=1S/C20H29FN2O3/c1-4-10-23-11-6-8-16(23)14-22-20(24)17-12-15(7-5-9-21)13-18(25-2)19(17)26-3/h4,12-13,16H,1,5-11,14H2,2-3H3,(H,22,24)/t16-/m0/s1
  • Key:OABRYNHZQBZDMG-INIZCTEOSA-N

Fallypride is a high affinity dopamine D2/D3 receptor antagonist used in medical research,[1] usually in the form of fallypride (18F) as a positron emission tomography (PET) radiotracer in human studies.[2][3]

References

  1. ^ Mukherjee J, Yang ZY, Das MK, Brown T (April 1995). "Fluorinated benzamide neuroleptics--III. Development of (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2, 3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer". Nuclear Medicine and Biology. 22 (3): 283–96. doi:10.1016/0969-8051(94)00117-3. PMID 7627142.
  2. ^ Mukherjee J, Christian BT, Dunigan KA, Shi B, Narayanan TK, Satter M, Mantil J (December 2002). "Brain imaging of 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors". Synapse. 46 (3): 170–88. doi:10.1002/syn.10128. PMID 12325044. S2CID 24852944.
  3. ^ Rieck RW, Ansari MS, Whetsell WO, Deutch AY, Kessler RM (February 2004). "Distribution of dopamine D2-like receptors in the human thalamus: autoradiographic and PET studies". Neuropsychopharmacology. 29 (2): 362–72. doi:10.1038/sj.npp.1300336. PMID 14627996.


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