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TFDP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AZE
Identifiers
Aliases	TFDP1, DP1, DRTF1, Dp-1, DILC, transcription factor Dp-1
External IDs	OMIM: 189902; MGI: 101934; HomoloGene: 38276; GeneCards: TFDP1; OMA:TFDP1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	113,641,473 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	13,378,448 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; trabecular bone; ; ventricular zone; ; bone marrow; ; stromal cell of endometrium; ; ganglionic eminence; ; rectum; ; olfactory zone of nasal mucosa; ; mucosa of esophagus; ; buccal mucosa cell;
	Top expressed in
	granulocyte; ; epiblast; ; ventricular zone; ; dermis; ; tail of embryo; ; abdominal wall; ; fetal liver hematopoietic progenitor cell; ; hair follicle; ; genital tubercle; ; primitive streak;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein domain specific binding; DNA-binding transcription factor activity; protein binding; transcription coactivator activity; transcription factor binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription regulator complex; nucleus; mitochondrion; nucleoplasm; cytosol; cytoplasm; RNA polymerase II transcription regulator complex;
Biological process	regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; cell cycle; cell population proliferation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; transcription, DNA-templated; regulation of transcription involved in G1/S transition of mitotic cell cycle; transcription by RNA polymerase II; negative regulation of G0 to G1 transition; positive regulation of transcription by RNA polymerase II; negative regulation of fat cell proliferation; epidermis development; anoikis; positive regulation of transcription, DNA-templated; regulation of cell cycle; regulation of DNA biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	7027
	21781
	ENSG00000198176
	ENSMUSG00000038482
	Q14186
	Q08639
	NM_007111
	NM_001291765; NM_001291766; NM_001291768; NM_009361; NM_001358991
	NP_009042
	NP_001278694; NP_001278695; NP_001278697; NP_033387; NP_001345920
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene.^[5]^[6]^[7]

Function

The E2F transcription factor family (see MIM 189971) regulates the expression of various cellular promoters, particularly those involved in the cell cycle. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription factors; see TFDP2 (MIM 602160).[supplied by OMIM]^[7]