Syntaxin binding protein 2

STXBP2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4CCA

Identifiers

STXBP2, FHL5, Hunc18b, MUNC18-2, UNC18-2, UNC18B, pp10122, Syntaxin binding protein 2

External IDs

OMIM: 601717; MGI: 107370; HomoloGene: 55530; GeneCards: STXBP2; OMA:STXBP2 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.2	Start	7,636,881 bp^[1]
Band	19p13.2	End	7,647,873 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8 A1.1\|8 1.92 cM	Start	3,680,955 bp^[2]
Band	8 A1.1\|8 1.92 cM	End	3,693,644 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

granulocyte

monocyte

mucosa of transverse colon

body of pancreas

upper lobe of left lung

right lung

right uterine tube

left testis

right lobe of thyroid gland

right testis

Top expressed in

granulocyte

neural layer of retina

yolk sac

superior frontal gyrus

lip

right kidney

submandibular gland

saccule

duodenum

stomach

More reference expression data

n/a

Gene ontology
Molecular function	protein binding syntaxin-1 binding syntaxin-3 binding
Cellular component	cytolytic granule tertiary granule SNARE complex azurophil granule specific granule apical plasma membrane extracellular exosome plasma membrane zymogen granule membrane extracellular region cytosol phagocytic vesicle
Biological process	protein transport neutrophil degranulation vesicle docking involved in exocytosis regulation of mast cell degranulation leukocyte mediated cytotoxicity vesicle-mediated transport exocytosis platelet degranulation transport cellular response to interferon-gamma
Sources:Amigo / QuickGO

Species

Human

Mouse


6813


20911


ENSG00000076944


ENSMUSG00000004626


Q15833


Q64324

RefSeq (mRNA)


NM_001127396 NM_001272034 NM_006949


NM_011503 NM_001357168

RefSeq (protein)


NP_001120868 NP_001258963 NP_008880


NP_035633 NP_001344097

Location (UCSC)

Chr 19: 7.64 – 7.65 Mb

Chr 8: 3.68 – 3.69 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Syntaxin-binding protein 2 is a protein that in humans is encoded by the STXBP2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076944 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004626 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ziegler SF, Mortrud MT, Swartz AR, Baker E, Sutherland GR, Burmeister M, Mulligan JT (Feb 1997). "Molecular characterization of a nonneuronal human UNC18 homolog". Genomics. 37 (1): 19–23. doi:10.1006/geno.1996.0515. PMID 8921365.
^ "Entrez Gene: STXBP2 syntaxin binding protein 2".

Further reading

Ibaraki K, Horikawa HP, Morita T, et al. (1995). "Identification of four different forms of syntaxin 3". Biochem. Biophys. Res. Commun. 211 (3): 997–1005. doi:10.1006/bbrc.1995.1910. PMID 7598732.
Hata Y, Südhof TC (1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Tellam JT, Macaulay SL, McIntosh S, et al. (1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4". J. Biol. Chem. 272 (10): 6179–86. doi:10.1074/jbc.272.10.6179. PMID 9045631.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Riento K, Galli T, Jansson S, et al. (1999). "Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells". J. Cell Sci. 111 (17): 2681–8. doi:10.1242/jcs.111.17.2681. PMID 9701566.
Riento K, Kauppi M, Keranen S, Olkkonen VM (2000). "Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells". J. Biol. Chem. 275 (18): 13476–83. doi:10.1074/jbc.275.18.13476. PMID 10788461.
Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
Baccon J, Pellizzoni L, Rappsilber J, et al. (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
Kauppi M, Wohlfahrt G, Olkkonen VM (2003). "Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3". J. Biol. Chem. 277 (46): 43973–9. doi:10.1074/jbc.M208315200. PMID 12198139.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Martin-Verdeaux S, Pombo I, Iannascoli B, et al. (2003). "Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis". J. Cell Sci. 116 (Pt 2): 325–34. doi:10.1242/jcs.00216. PMID 12482918.
Houng A, Polgar J, Reed GL (2003). "Munc18-syntaxin complexes and exocytosis in human platelets". J. Biol. Chem. 278 (22): 19627–33. doi:10.1074/jbc.M212465200. PMID 12649283.
Schraw TD, Lemons PP, Dean WL, Whiteheart SW (2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". Biochem. J. 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. PMC 1223584. PMID 12773094.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Syntaxin-binding protein 2

Membrane protein: vesicular transport proteins (TC 1F)

Synaptic vesicle

Q-SNARE	SNAP25 SNAP29 Syntaxin STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 STX10 STX11 STX12 STX16 STX17 STX18 STX19 Munc-18: STXBP1 STXBP2 STXBP3 STXBP4 STXBP5 STXBP6
R-SNARE	Synaptobrevin/VAMP: VAMP1 VAMP2 VAMP3

Other

Small GTPase: RAB3A

Coatomer
- COPA
- COPB1
- COPB2
- COPD/Archain
- COPE
- COPG
- COPG2
- COPZ1
- COPZ2

Small GTPase: ARF

Coatomer
- SEC23A/SEC24A
- SEC13/SEC31

Small GTPase: SAR1A

Other/ungrouped

Vesicle formation

Adaptor protein complex 1:	AP1AR AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3
Adaptor protein complex 2:	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1
Adaptor protein complex 3:	AP3B1 AP3B2 AP3D1 AP3M1 AP3M2 AP3S1 AP3S2
Adaptor protein complex 4:	AP4B1 AP4E1 AP4M1 AP4S1
LMAN1
LYST
BLOC-1:	DTNBP1 BLOC153
BLOC-2:	HPS3 HPS5 HPS6
BLOC-3:	HPS1 HPS4
Coats:	Retromer TIP47

Dynamin
- DNM1
- DNM2
- DNM3

Other

Sorting nexins

SYNRG

See also vesicular transport protein disorders

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

Read other articles:

مركز (هندسة رياضية)

مركز_(هندسة_رياضية)

لمعانٍ أخرى، طالع مركز (توضيح). مركز الدائرة في الهندسة الرياضية، مركز جسم ما هو النقطة التي تقع في منتصف الجسم.[1] في الدائرة مركز الدائرة هو النقطة التي تكون متساوية البعد عن جميع النقاط في محيط الدائرة. بشكل مشابه يعرف مركز الكرة على أنها النقطة المتساوية البعد �...

Asosiasi Guru Penulis Indonesia

Asosiasi_Guru_Penulis_Indonesia

Asosiasi Guru Penulis IndonesiaSingkatanAGUPENATanggal pendirian28 November 2006Kantor pusatJalan Roda Hias, RT 004/02 No 09, Cikareo, Kelurahan Serpong, Kecamatan Serpong, Kota Tangerang Selatan Kode Pos 15310, BantenKetua UmumNaijan, S.Pd., M.Pd. Asosiasi Guru Penulis Indonesia (disingkat AGUPENA) adalah organisasi di Indonesia yang bernaung di bawah bendera Yayasan Agupena. Organisasi ini beranggotakan guru/pensiunan guru, dosen/pensiunan dosen, dan tenaga kependidikan/pensiunan tenaga kep...

Carnauba wax

Natural plant wax from leaves of the carnauba palm Carnauba wax Carnauba (/kɑːrˈnɔːbə, -ˈnaʊ-, -ˈnuː-, -nɑːˈuː-/;[1][2] Portuguese: carnaúba [kaʁnaˈubɐ]), also called Brazil wax and palm wax, is a wax of the leaves of the carnauba palm Copernicia prunifera (synonym: Copernicia cerifera), a plant native to and grown only in the northeastern Brazilian states of Ceará, Piauí, Paraíba, Pernambuco, Rio Grande do Norte, Maranhão and Bahia.[3] It...

Украинский национальный союз

Украинский_национальный_союз

У этого термина существуют и другие значения, см. Национальный союз. Украинский национальный союзукр. Український Національний Союз Герб Украинского национального союза Флаг Украинского национального союза Другие названия УНС Идеология Ирредентизм, украинский народн...

Eureka! (museum)

Eureka!_(museum)

Children's museum in Yorkshire, England This article includes a list of general references, but it lacks sufficient corresponding inline citations. Please help to improve this article by introducing more precise citations. (December 2021) (Learn how and when to remove this template message) Eureka! The National Children's MuseumExterior of Eureka!Established1992Location53°43′12″N 1°51′18″W / 53.72000°N 1.85500°W / 53.72000; -1.85500TypeChildren's MuseumVisi...

Jean Goldkette

French-American jazz pianist and bandleader (1893-1962) Jean GoldketteBackground informationBirth nameJohn Jean GoldketteBorn(1893-03-18)March 18, 1893Valenciennes, France(Disputed)DiedMarch 24, 1962(1962-03-24) (aged 69)Los Angeles, California, U.S.GenresJazz, dixielandOccupation(s)Musician, bandleaderInstrument(s)PianoMusical artist John Jean Goldkette (March 18, 1893 – March 24, 1962) was a jazz pianist and bandleader. Life Goldkette was reportedly born on March 18, 1893, in Val...

Lignes de Blaschko

Lignes_de_Blaschko

Les lignes de Blaschko sont des motifs cutanés non aléatoires et normalement invisibles sur la peau et des phanères, mais qui (extrêmement rarement) peuvent devenir visibles chez l'être humain[1]. Des marbrures et/ou des motifs caractéristiques apparaissent alors sur la peau. Elles sont décrites pour la première fois en 1901 lors du 7e Congrès de la société allemande de dermatologie, par le dermatologue allemand Alfred Blaschko, à partir des observations qu'il avait faites su...

Mitsubishi Eclipse

Mitsubishi_Eclipse

Mitsubishi EclipseInformasiProdusenMitsubishi MotorsDiamond-Star MotorsMasa produksi1990–2012PerakitanNormal, Illinois, Amerika SerikatBodi & rangkaKelasKompak sportKronologiPendahuluMitsubishi CordiaPenerus- Mitsubishi Eclipse adalah mobil kompak sport yang diproduksi oleh Mitsubishi Motors. Mobil ini dijual pada tahun 1989 sampai 2011 di kebanyakan negara-negara yang memakai setir kiri (misalnya Amerika Serikat, Kanada, Eropa Daratan dan Taiwan). Model bodi konvertibel ditambahkan pad...

Nōgata, Fukuoka

Nōgata,_Fukuoka

Nōgata 直方市Kota BenderaLambangLokasi Nōgata di Fukuoka PrefectureNegara JepangWilayahKyūshūPrefektur FukuokaPemerintahan • WalikotaNobuhiro ŌtsukaLuas • Total61,8 km2 (239 sq mi)Populasi (Oktober 1, 2015) • Total57.146 • Kepadatan924,7/km2 (23,950/sq mi)Zona waktuUTC+9 (Waktu Standar Jepang)Simbol • PohonMagnolia grandiflora Cornus kousa• BungaTulipa Lilium Cosmos NarcissusAlamat7-1 Tonomachi...

Dewan Perwakilan Rakyat Kabupaten Aceh Selatan

Dewan_Perwakilan_Rakyat_Kabupaten_Aceh_Selatan

Dewan Perwakilan Rakyat Kabupaten Aceh Selatan DPRK Aceh Selatan2019-2024JenisJenisUnikameral Jangka waktu5 tahunSejarahSesi baru dimulai2 September 2019PimpinanKetuaAmiruddin (PNA) sejak 8 Januari 2021 Wakil Ketua ITeuku Bustami, S.E. (Demokrat) sejak 28 Oktober 2019 Wakil Ketua IIAdi Samridha, S.Pd.I. (PA) sejak 24 Agustus 2021 KomposisiAnggota30Partai & kursi NasDem (3) PKB (2) Hanura (1) Demokrat (4) PKPI (2) ...

コルク

この記事は検証可能な参考文献や出典が全く示されていないか、不十分です。出典を追加して記事の信頼性向上にご協力ください。（このテンプレートの使い方）出典検索?: コルク – ニュース · 書籍 · スカラー · CiNii · J-STAGE · NDL · dlib.jp · ジャパンサーチ · TWL（2017年4月）コルクを打ち抜いて作った瓶の栓コルク（木栓、�...

Un tram che si chiama Desiderio (opera teatrale)

Un_tram_che_si_chiama_Desiderio_(opera_teatrale)

Un tram che si chiama DesiderioOpera teatrale in tre atti La locandina d'epoca AutoreTennessee Williams Titolo originaleA Streetcar named Desire Lingua originaleinglese Generedramma Composto nel1947 Prima assoluta3 dicembre 1947New York Prima rappresentazione italiana21 gennaio 1949Teatro Eliseo di Roma PremiPremio Pulitzer 1947 per miglior dramma Personaggi Blanche DuBois Stanley Kowalsky Stella DuBois Kowalsky Mitch Steve Pablo Eunice Una donna di colore, un passante, un marinaio, un vendit...

Umberto Veronesi

Umberto_Veronesi

Italian oncologist and politician (1925–2016) Umberto VeronesiBorn(1925-11-28)28 November 1925Milan, Kingdom of ItalyDied8 November 2016(2016-11-08) (aged 90)Milan, ItalyNationalityItalianAlma materUniversity of MilanKnown forBreast-conserving surgery in breast cancer treatment with the invention of the technique of quadrantectomyScientific careerInstitutionsEuropean Institute of Oncology President of the Italian NuclearSafety AgencyIn office5 November 2010 – 3 Nov...

Medal for Gallantry

Medal_for_Gallantry

For the Greek decoration, see Medal for Gallantry (Greece). AwardMedal for GallantryObverse of medal and ribbonTypeMedalAwarded foracts of gallantry in action in hazardous circumstances[1]Presented byAustraliaEligibilityMembers of the Australian Defence ForcePost-nominalsMGStatusCurrently awardedEstablished15 January 1991First awarded1996Last awarded2024 Special HonoursTotal76[2]Order of Wear[3]Next (higher)Nursing Service Cross[3]Next (lower)Bravery ...

David Howarth

British academic and politician For the historian and author, see David Howarth (author). This biography of a living person needs additional citations for verification. Please help by adding reliable sources. Contentious material about living persons that is unsourced or poorly sourced must be removed immediately from the article and its talk page, especially if potentially libelous.Find sources: David Howarth – news · newspapers · books · scholar · JS...

فريزة (إيطاليا)

فريزة_(إيطاليا)

فريزة علم شعار الاسم الرسمي (بالإيطالية: Varese)‏ الإحداثيات 45°49′00″N 8°50′00″E / 45.816666666667°N 8.8333333333333°E / 45.816666666667; 8.8333333333333 [1] تقسيم إداري البلد إيطاليا (2 يونيو 1946–)[2][3] التقسيم الأعلى مقاطعة فَرِيزة عاصمة لـ مقاطعة فَرِيزة...

مارثا فينيارد

مارثا فينيارد معلومات جغرافية الإحداثيات 41°24′00″N 70°37′00″W / 41.4°N 70.616666666667°W / 41.4; -70.616666666667 [1] [2] المسطح المائي المحيط الأطلسي المساحة 226.57 كيلومتر مربع الطول 33 كيلومتر أعلى ارتفاع (م) 24 متر[3] الحكومة البلد الولايات المتحدة[3]&#...

Hog Wild (1930 film)

Hog_Wild_(1930_film)

1930 film Hog WildDirected byJames ParrottWritten byH. M. WalkerStan LaurelProduced byHal RoachStarringStan LaurelOliver HardyFay HoldernessDorothy GrangerCinematographyGeorge StevensEdited byRichard CurrierMusic byWilliam AxtHal RoachDistributed byMetro-Goldwyn-MayerRelease date May 31, 1930 (1930-05-31) Running time19:22CountryUnited StatesLanguageEnglish Hog Wild is a 1930 American pre-Code Laurel and Hardy film, directed by James Parrott. Plot Ollie is embroiled in a futile...

山口俊

山口俊読売ジャイアンツ時代（2019年10月9日東京ドーム）基本情報国籍日本出身地大分県中津市生年月日 (1987-07-11) 1987年7月11日（37歳）身長体重 187 cm98 kg選手情報投球・打席右投右打ポジション投手プロ入り 2005年高校生ドラフト1巡目初出場 NPB / 2006年6月29日MLB / 2020年7月26日最終出場 MLB / 2020年9月28日NPB / 2022年4月8日経歴（括弧内はプロチーム在籍年度）柳ヶ浦高�...

Westfield Oakridge

Westfield_Oakridge

Shopping mall in San Jose, California Westfield OakridgeFrontage from Blossom Hill RoadLocationSan Jose, CaliforniaCoordinates37°15′09″N 121°51′42″W / 37.252492°N 121.861668°W / 37.252492; -121.861668Address925 Blossom Hill Road San Jose, CA 95123Opening date1971 (as Oakridge Mall)DeveloperThe Hahn CompanyManagementWestfield GroupOwnerWestfield GroupNo. of stores and services160+No. of anchor tenants5Total retail floor area1,139,602 sq ft (105,872...