Padma Shri Shanti Swarup Bhatnagar Prize Dr. B. C. Roy Award Uttar Pradesh Vigyan Ratna Dr. H. B. Dingley Memorial Award Shakuntala Amirchand Memorial Award Rajib Goyal Award Amrut Modi Unichem Award Maj Gen. Amir Chand Award Dr. S. T. Achar Award Best Poster Paper Award Best Paper Award Vocational Excellence Prize
Dr. Pradhan's extensive clinical research in the area of muscular dystrophy has led to the discovery of five new clinical signs, each indicative of a specific type of the disease.Sanjay Gandhi Post Graduate Institute of Medical Sciences circular.[1]
Pradhan brought about many changes at the IHBAS. He was instrumental in updating and elaborating the signage, displays and boards and constructing patient shelters. The electrophysiology Lab was started where he arranged for the setting up of modern equipment like 32 Channels Polysomnography, Nicolet 32 Channels digital Portable Electroencephalography and Electromyography.[citation needed]
Pradhan lives in Lucknow, along the Rae Bareilly Road, in Uttar Pradesh.[5]
Pradhan sign or Valley sign: The first of the signs he discovered is related to Duchenne muscular dystrophy (DMD).[6] He discovered that the DMD patients tend to suffer visible enlargement of the infraspinatus and deltoid muscles, which when contracted shows partial wastage. Pradhan clarified that this revealed a valley between the two mounts, visible behind the outstretched shoulders and called it valley sign.[7] The sign was evident in patients with little calf muscle enlargement and visibly positive in DMD cases with 90% sensitivity. The sign was later renamed as Pradhan Sign, on recommendation from the American Academy of Pediatrics.[1][6]
Poly hill sign: Poly Hill Sign,[8] the second of the signs Pradhan discovered related to facioscapulohumeral muscular dystrophy(FSHD).[6] Pradhan noticed that the shoulder abduction of a patient with external rotation resulted in the formation of six bulges on the back of the shoulders and arms and named it poly hill due to the bulges.[1] He has also reported of an extra hill in one of the cases he attended to.[9]
Shank sign: The third sign, Shank Sign,[10] is related to myotonic dystrophy type 1 (DM-1). When patients suffering from the disease abduct their arms to 90 degrees, a tapering of the upper arm musculature is observed when examined from behind, due to wasting of the biceps, triceps and forearm muscles. This gives a visual resemblance of the shanks of an animal. This sign had an occurrence on 78% of the patients examined by Dr. Pradhan.[6][10]
Calf-head sign: miyoshi myopathy patients, when they raise their arms with shoulders abducted and elbows flexed to 90 degrees, returned a visual similar to a calf head trophy, on magnetic resonance imaging.[11] The test returned positive on 10 of the 15 patients examined by Dr. Pradhan.[6][11]
Diamond on quadriceps sign: The sign is related to dysferlinopathy.[6] A clinical study of 31 patients revealed that the patients with the disease developed a diamond shaped bulge on the upper half of the anterolateral aspect of thighs when they stand with knees slightly bent, thereby putting pressure on the quadriceps muscles. The bulge did not appear when the patients were sitting or standing. MRI images confirmed focal bulging out of muscles.[12] The occurrence is observed on 66% of the patients.
Electrophysiological techniques
Pradhan is credited with two new techniques related to electrophysiology.[1]
The first technique is related to the non-invasive study of intercostal nerves.[13] The technique is reported to have been included in a text book published from the US, calling it as Pradhan Method.[1] The technique advises surface stimulation of the intercostal skin while using specific sites of the rectus abdominis muscle for surface recording. This helps in early detection of the symptoms in patients with Guillain–Barré syndrome. It is also used in the diagnosis of diabetic thoraco abdominal neuropathy.[1]
The second technique involves stimulating the intercostal nerves to study the somatosensory evoked potentials, for localizing the non compressive spinal cord lesions.[14]
Pradhan was successful in elucidating the mechanisms of neurophysiological F‑response generation in healthy and diseased bodies and discovered a phenomenon, F-response multiplicity, a symptom of the lower motor neuron disorder. Pradhan asserted, by way of his findings, loss of early components and scattering of late components are responsible for the different F-response parameters in the lower neuron disorders.[1] He has also demonstrated standardized variables of contraction enhanced H‑reflex called R‑1 response and its utility in nerve root lesions where H-reflex is not electable. This was ratified by many researchers.[1]
Research on Japanese Encephalitis
Pradhan found out that the Japanese‑B encephalitis (JE) sometimes produced selective lesions on the substrata nigra and this observation has assisted in eliciting a clue in explaining the early onset of Parkinson's disease.[15] This was ratified by Japanese scientists with the help of an animal model of the disease using rats.[1] His findings led to a new clinical entity called Parainfectious conus myelitis, thus drawing an explanation for the unexplained urinary symptoms in young patients. He is credited with the discovery of the role of immunoglobins in acute disseminated encephalomyelitis, a finding confirmed by many other researchers.[1]
Research on Epilepsy
Pradhan has done extensive research on epilepsy.[16] His studies revealed that patients are likely to suffer from chronic epileptogenesis with poor seizure outcome if gliosis is present around their lesions. He averred that the patients with neurocysticercosis are prone to developing perilesional gliosis, may develop drug resistance during anti‑epileptic drug (AED) therapy and may suffer seizures if the drug is stopped. He has also explained tickling seizures[17] and micturition induced reflex epilepsy,[18] both reported to be first time findings.[1]
Research on Hirayama type Monomelic Amyotrophy
Pradhan has done research on Hirayama type monomelic amyotrophy,[19] a disease described by Dr. Hirayama in 1959.[20] In 1977, he published a report explaining the features of diagnostic magnetic resonance imaging.[1] The diagnosis of the disease remaining purely clinical, it is reported that his findings are the only objective diagnostic method. Dr. Hirayama, in 2003, published a paper confirming Dr. Pradhan's findings.[1]
Other studies
Pradhan is also credited with other findings such as:
If the process is of long duration, patients may develop central pontine myelinolysis, irrespective of whether the correction of hyponatremia is kept slow.[1][21]
Description of MRI and other features of acute endosulphan poisoning and its similarities with the MRI features of Huntington's disease and suggested neurotoxic mechanism by blocking mitochondrial energy metabolism.[1][23]
Description of a new method for extracting lipid from muscle tissues for NMR studies.[24]
Description of micturition induced reflex epilepsy.[18]
The Government of India, in 2014, honoured Dr. Sunil Pradhan, by awarding him the civilian honour of Padma Shri.[4] He has received many other awards such as:
Pradhan has published several research papers in peer reviewed journals, both national and international in circulation.[28] A random selection of his articles features:
Pradhan, Sunil K.; Kamble, Nitin M.; Pillai, Aravind S.; Gaikwad, Satish S.; Khulape, Sagar A.; Reddy, M.R.; Mohan, C. Madhan; Kataria, Jag Mohan; Dey, Sohini (December 2014). "Recombinant nucleocapsid protein based single serum dilution ELISA for the detection of antibodies to infectious bronchitis virus in poultry". Journal of Virological Methods. 209: 1–6. doi:10.1016/j.jviromet.2014.08.015. PMID25173423.
The National Center for Biotechnology Information of the United States National Library of Medicine has published the abstracts of over 750 papers published by Dr. Pradhan.[28]Nanojamians, a blog providing information on technological advancement in neuro sciences, has also listed many of his papers.
Controversy
It was around 12 noon on Monday when the judge came to the OPD and asked to be seen by me. As is the normal procedure, I requested that the case should first go to a resident doctor for preparation of a medical case sheet. But he insisted to be seen by me only. He carried no medical file with him. Also, no doctor had referred him to me. Anyway, I called him in. As I was busy seeing a patient, I could only offer a chair to the lady accompanying the judge. I did not have more chairs to offer to the judge. He, however, left, Dr. Pradhan said about the incident.[2]
On 9 October 2006, Dr. Pradhan received a court summons from the Lucknow bench of the Allahabad High Court, on charges of contempt of court for allegedly ignoring a sitting judge of Allahabad High Court, to present himself before the judge the next day. Dr. Pradhan appeared before the judge at his chamber, along with the Advocate General and the Additional Advocate General of Uttar Pradesh and was asked to tender a written apology, which included an assurance to not to repeat the mistake in future. He duly did so and was released without a sentence. Reports about the incident appeared in the media, and drew comments from the public and the law circles. The comments of the judge, however, was not reported.[2]
Later, acting on the news report, the Governor of Uttar Pradesh, T. V. Rajeswar, ordered an enquiry into the incident. The Principal Secretary to the Governor contacted Sanjay Gandhi Post Graduate Institute of Medical Sciences and asked for a report from the management of the institute. Dr. Pradhan's statement was recorded and a report was submitted to the Governor. The details about the action taken are not known.[29]
^ ab"Padma Awards Announced". Circular. Press Information Bureau, Government of India. 25 January 2014. Archived from the original on 22 February 2014. Retrieved 23 August 2014.
^Pradhan, S.; Pandey, N.; Shashank, S.; Gupta, R. K.; Mathur, A. (1 November 1999). "Parkinsonism due to predominant involvement of substantia nigra in Japanese encephalitis". Neurology. 53 (8): 1781–6. doi:10.1212/wnl.53.8.1781. PMID10563628. S2CID25764800.
^Pradhan, Sunil; Kathuria, Manoj K.; Gupta, Rakesh K. (2000). "Perilesional gliosis and seizure outcome: A study based on magnetization transfer magnetic resonance imaging in patients with neurocysticercosis". Annals of Neurology. 48 (2): 181–187. doi:10.1002/1531-8249(200008)48:2<181::aid-ana7>3.0.co;2-c. PMID10939568. S2CID24449302.
