Succinylsulfathiazole

Succinylsulfathiazole
Clinical data
ATC code
Identifiers
  • 4-oxo-4-({4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}amino)butanoic acid
CAS Number
PubChem CID
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.003.765 Edit this at Wikidata
Chemical and physical data
FormulaC13H13N3O5S2
Molar mass355.38 g·mol−1
3D model (JSmol)
  • OC(=O)CCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2nccs2
  (verify)

Succinylsulfathiazole (also known as sulfasuxidine) is a sulfonamide.[1][2] It is also spelled as succinylsulphathiazole. It is a white or yellow-white crystalline powder. It dissolves in aqueous solutions of alkali hydroxides and carbonates but is very slightly soluble in water.

It is classified as ultra long-acting drug. About 95% of the drug remains in the intestine and only 5% is hydrolyzed, slowly, to sulfathiazole and is absorbed.

The drug is used for its antibacterial activity in the GIT. The dose is 10g - 20g daily in divided doses.

The Succinyl group is attached to form a prodrug for the controlled release of the drug sulfathiazole.

References

  1. ^ Poth EJ, Knotts FL (February 1942). "Clinical use of Succinylsulfathiazole". Archives of Surgery. 44 (2): 208. doi:10.1001/archsurg.1942.01210200024002. ISSN 0004-0010.
  2. ^ Dixon CF, Benson RE (October 1944). "Closure of Colonic Stoma: Improved Results With Combined Succinylsulfathiazole and Sulfathiazole Therapy". Annals of Surgery. 120 (4): 562–571. doi:10.1097/00000658-194410000-00012. PMC 1618178. PMID 17858511.
Stub icon

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.