The song's title and lyrics are a call for its listeners to "stand" up for themselves, their communities, and what they believe in. Like nearly all of Sly & the Family Stone's songs, Sylvester "Sly Stone" Stewart was credited as the sole songwriter.
The original mix of "Stand!" garnered a warm, yet unenthusiastic, reaction when Sly Stone had an early acetate of the record played in a San Francisco club. As a result, Stone went back into the studio and had the song's final section, a fevered gospel music-styled break, rerecorded. Most of the Family Stone was unavailable for the session, and Stone resorted to using mostly studio musicians for the rerecorded section.