Li was drafted by Carlton with their second selection and twenty-eighth overall in the 2017 AFL Women's draft. Carlton's coach, Damien Keeping, said that she "is a prolific ball winner and will be an asset to our midfield".[1] She chose to wear the number 35 guernsey as a tribute to Patrick Dangerfield, who she models her game on.[4] She made her debut in the eight point win against Collingwood at Ikon Park in the opening round of the 2018 season.[9] Li appeared in every game of her debut season, but chose to leave Carlton so she could return to her home state with her partner and for her work,[10] even after re-signing for the 2019 season.[11] Carlton received the forty-second pick in the 2018 AFL Women's draft as compensation, but were disappointed to lose her, with Nicole Graves, Carlton's General Manager of Women's Football, saying "Soph is a terrific player and person so we'll be sad to see her go, but we understand her decision and reasoning behind wanting to return to Adelaide".[10]
Adelaide
Li joined Adelaide in September 2018, so that she could return to her work as a paramedic in Adelaide.[3] She made her debut for Adelaide against Western Bulldogs at Norwood Oval in the opening round of the 2019 season.[12][13] She helped Adelaide claim their second premiership, playing every match in the season[11] and helping beat her former club Carlton at Adelaide Oval in the Grand Final on her birthday.[14][15] In July 2020, Li announced her retirement from the AFLW.[16]