After not playing a game in her first AFLW season in 2018, she was delisted by Brisbane. However, they re-signed her as a free agent before the 2019 season, and she made her AFLW debut in the Lions' round 4 game against Western Bulldogs at Whitten Oval on 23 February 2019.[3]
At the end of the 2021 season, Keeffe announced her retirement after 11 games with the Lions, citing mental health challenges.[4]