Somatomedin B

Somatomedin B domain
Identifiers
SymbolSomatomedin_B
PfamPF01033
InterProIPR001212
SMARTSO
PROSITEPDOC00453
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB2cqwA:25-65 1s4gA:20-63 1ssuA:20-63 1oc0B:20-63

Somatomedin B is a serum factor of unknown function, is a small cysteine-rich peptide, derived proteolytically from the N-terminus of the cell-substrate adhesion protein vitronectin.[1] Cys-rich somatomedin B-like domains are found in a number of proteins,[2] including plasma-cell membrane glycoprotein (which has nucleotide pyrophosphate and alkaline phosphodiesterase I activities)[3] and placental protein 11 (which appears to possess amidolytic activity).

The SMB domain of vitronectin has been demonstrated to interact with both the urokinase receptor and the plasminogen activator inhibitor-1 (PAI-1) and the conserved cysteines of the NPP1 somatomedin B-like domain have been shown to mediate homodimerization.[4] As shown in the following schematic representation below the SMB domain contains eight Cys residues, arranged into four disulfide bonds. It has been suggested[by whom?] that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, provided that the Cys25-Cys31 disulfide bond is preserved. The three-dimensional structure of the SMB domain is extremely compact and the disulfide bonds are packed in the centre of the domain forming a covalently bonded core.[5] The structure of the SMB domain presents a new protein fold, with the only ordered secondary structure being a single-turn alpha-helix and a single-turn 3(10)-helix.[6] 

        xxCxxxxxxCxxxxxxxxxCxCxxxCxxxxxCCxxxxxCxxxxx
                           ********************

'C': conserved cysteine probably involved in a disulfide bond. '*': position of the pattern.

Human proteins containing this domain

ENPP1; ENPP2; ENPP3; PRG4; SUSD2; VTN;

References

  1. ^ Jenne D, Stanley KK (1987). "Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the "pexin" family and a model for their evolution". Biochemistry. 26 (21): 6735–6742. doi:10.1021/bi00395a024. PMID 2447940.
  2. ^ Jenne D (1991). "Homology of placental protein 11 and pea seed albumin 2 with vitronectin". Biochem. Biophys. Res. Commun. 176 (3): 1000–1006. doi:10.1016/0006-291X(91)90381-G. PMID 1710108.
  3. ^ Rebbe NF, Tong BD, Finley EM, Hickman S (1991). "Identification of nucleotide pyrophosphatase/alkaline phosphodiesterase I activity associated with the mouse plasma cell differentiation antigen PC-1". Proc. Natl. Acad. Sci. U.S.A. 88 (12): 5192–5196. Bibcode:1991PNAS...88.5192R. doi:10.1073/pnas.88.12.5192. PMC 51838. PMID 1647027.
  4. ^ Gijsbers R, Ceulemans H, Bollen M (2003). "Functional characterization of the non-catalytic ectodomains of the nucleotide pyrophosphatase/phosphodiesterase NPP1". Biochem. J. 371 (Pt 2): 321–330. doi:10.1042/BJ20021943. PMC 1223305. PMID 12533192.
  5. ^ Dyson HJ, Kamikubo Y, Kroon G, Curriden S, Neels JG, Churchill MJ, Dawson P, Jagielska A, Scheraga HA, Loskutoff DJ, De Guzman R, OBdziej S (2004). "Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin". Biochemistry. 43 (21): 6519–6534. doi:10.1021/bi049647c. PMID 15157085.
  6. ^ Carrell RW, Zhou A, Read RJ, Huntington JA, Pannu NS (2003). "How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration". Nat. Struct. Biol. 10 (7): 541–544. doi:10.1038/nsb943. PMID 12808446. S2CID 26086796.
This article incorporates text from the public domain Pfam and InterPro: IPR001212

Read other articles:

César Rincón

Colombian matador (born 1965) Julio César Rincón Ramírez is a Colombian matador born in Bogotá on 5 September 1965. César Rincón in 2005. References Biographical notice on Mundo Toro Biographical notice Portal Taurino Interview on the El Mundo newspaper Authority control databases International ISNI VIAF National France BnF data Other IdRef This biographical article about bullfighting in Colombia is a stub. You can help Wikipedia by expanding it.vte

 

 

Tarun Kant

Indian engineering professor (born 1946) This article is an orphan, as no other articles link to it. Please introduce links to this page from related articles; try the Find link tool for suggestions. (July 2021) Tarun KantBorn (1946-08-01) August 1, 1946 (age 77)IndiaOccupation(s)Teacher and researcherSpouseRekha SrivastavaChildren2Scientific careerFieldsCivil engineeringInstitutionsIndian Institute of Technology BombayDoctoral advisorProf C.K Ramesh Tarun Kant,[1] an institute c...

 

 

Harran

Untuk kegunaan lain, lihat Haran. Untuk Pertempuran, lihat Pertempuran Harran. Harran حرانܚܪܐܢHarranLokasi Harran di TurkiTampilkan peta TurkeyHarranHarran (Near East)Tampilkan peta Near EastKoordinat: 36°52′39″N 39°02′02″E / 36.87750°N 39.03389°E / 36.87750; 39.03389Koordinat: 36°52′39″N 39°02′02″E / 36.87750°N 39.03389°E / 36.87750; 39.03389Negara TurkiKawasanAnatolia TenggaraProvinsiŞanlıurfaPemerintahan...

Sulis

SulisGoddess of Healing, water, hot springs and cursesMajor cult centreBath (Aquae Sulis)EquivalentsRoman equivalentMinervaCeltic water deity Gilt bronze head from the cult statue of Sulis Minerva from the Temple at Bath, found in Stall Street in 1727 and now displayed at the Roman Baths (Bath). In the localised Celtic polytheism practised in Great Britain, Sulis was a deity worshiped at the thermal spring of Bath. She was worshiped by the Romano-British as Sulis Minerva, whose votive objects...

 

 

Pokémon Go

Pokémon Go Publikasi 6 Juli 2016 AUS: 6 Juli 2016 NA: 6 Juli 2016[note 1] EU: 13 Juli 2016[note 1] JP: 22 Juli 2016 VersiDaftarAndroid: 0.277.2 (17 Juli 2023)iOS: 0.277.2 (17 Juli 2023) GenreRealitas tertambahModel bisnisFree-to-play dan in-app purchases Bahasa Daftar Inggris, Italia, Jepang, Jerman, Prancis, Spanyol dan Tionghoa 60 Karakteristik teknisSistem operasiAndroid dan iOS PlatformAndroid, iOS dan iPadOS MesinUnityModePermainan video pemain tunggal dan permainan vide...

 

 

Liu Qi (politikus)

Halaman ini berisi artikel tentang politikus Tiongkok. Untuk tokoh lain, lihat Liu Qi. Dalam nama Tionghoa ini, nama keluarganya adalah Liu. Liu Qi刘淇Liu Qi Sekretaris Partai Komunis BeijingMasa jabatan22 Oktober 2002 – 3 Juli 2012PendahuluJia QinglinPenggantiGuo JinlongPresiden Komite Penyelenggara Beijing untuk Permainan OlimpiadeMasa jabatan29 Agustus 2004 – 24 Agustus 2008PemimpinJacques RoggePendahuluGianna Angelopoulos-DaskalakiPenggantiSebastian CoeWalikota Bei...

Neville Hill TMD

Train Maintenance Depot in West Yorkshire, England Neville Hill TMDNeville Hill depotLocationLocationLeeds, EnglandCoordinates53°47′32″N 1°30′18″W / 53.7923°N 1.5051°W / 53.7923; -1.5051OS gridSE325330CharacteristicsOwnerNetwork RailOperatorNorthern TrainsDepot code50B (1948–1960)[1]55H (1960–1973)[1]NL (1973–present)[1]TypeDiesel, HST, DMU, EMUHistoryOpened1904OriginalNorth Eastern RailwayPost-groupingLNER Neville Hill is a ra...

 

 

St. Augustine Town Plan Historic District

Historic district in Florida, United States United States historic placeSt Augustine Town Plan Historic DistrictU.S. National Register of Historic PlacesU.S. National Historic Landmark District Gonzalez-Alvarez House, an NHL itself and contributing property to the districtShow map of FloridaShow map of the United StatesLocationRoughly bounded by Grove Ave, the Matanzas River, and South and Washington Sts., St. Augustine, FloridaCoordinates29°53′31″N 81°18′51″W / 29.8...

 

 

Przemysław Matyjaszek

Polish judoka Przemysław MatyjaszekPrzemysław Matyjaszek, December 2012, Training at the UKS Dwójka Judo Tarnowskie Góry clubPersonal informationBorn (1978-04-24) 24 April 1978 (age 46)Ruda Śląska, PolandOccupationJudokaSportCountryPolandSportJudoWeight class–100 kgAchievements and titlesOlympic Games5th (2008)World Champ.13th (2001)European Champ. (2008) Medal record Men's judo Representing  Poland European Championships 2008 Lisbon –100 kg 2007 Warsaw Open World Juniors ...

Illinois Public Media

Broadcasting non-profit Campbell Hall at the University of Illinois, home of Illinois Public Media Illinois Public Media, previously WILL AM-FM-TV, is a not-for-profit organization located within the College of Media at the University of Illinois Urbana-Champaign, which is responsible for the university's public media service activities. It manages three university educational broadcasting stations licensed to Urbana, Illinois, United States: NPR member stations WILL (580 AM) and WILL-FM (90....

 

 

Pelabuhan Olimpiade Portsmouth

Artikel ini sebatang kara, artinya tidak ada artikel lain yang memiliki pranala balik ke halaman ini.Bantulah menambah pranala ke artikel ini dari artikel yang berhubungan atau coba peralatan pencari pranala.Tag ini diberikan pada Oktober 2022. Pelabuhan Olimpiade Portsmouth (bahasa Inggris: Portsmouth Olympic Harbour) adalah pelabuhan yang terletak di Kingston,[1][2] Ontario. Untuk Olimpiade Musim Panas 1976 di Montreal, tempat ini menjadi tuan rumah acara berlayar.[3...

 

 

2017 UCI Road World Championships

90-th championship of bikee sports 2017 UCI Road World ChampionshipsBergenLocation within NorwayShow map of VestlandBergenBergen (Norway)Show map of NorwayVenueBergen, NorwayDate(s) (2017-09-17 - 2017-09-24)17–24 September 2017Coordinates60°23′22″N 5°19′48″E / 60.38944°N 5.33000°E / 60.38944; 5.33000Events12← 20162018 → Events at the 2017 UCIRoad World ChampionshipsParticipating nationsQualificationElite eventsElite road racemen...

Stealth game

Video game genre Not to be confused with Stealth (video game). Part of a series onAction games Subgenres Action-adventure Metroidvania Battle royale Fighting Beat 'em up Hack and slash Platform fighter Platform Rhythm Action RPG Shooter Artillery Arena First-person Hero Light gun Third-person Tactical Shoot 'em up Bullet hell Twin-stick Sports Racing Stealth Survival Vehicle sim Topics Capture the flag Cover system First-person shooter engine Free look Quick time event WASD keys Lists List of...

 

 

Damián 666

Mexican professional wrestler In this Spanish name, the first or paternal surname is Carrera and the second or maternal family name is Gómez. Damián 666Gomez in 2007Birth nameLeonardo Carrera GómezBorn (1961-07-09) July 9, 1961 (age 63)[1]Tijuana, Baja California, Mexico[1][2]FamilyBestia 666 (son)Professional wrestling careerRing name(s)Caballero 2000[1]Ultraman 2000/Ultraman II[1]Amigo Ultra[1]Damien/Damián[1]Damián 6...

 

 

History of the Turks and Caicos Islands

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: History of the Turks and Caicos Islands – news · newspapers · books · scholar · JSTOR (October 2016) (Learn how and when to remove this message) Turks and Caicos on a 1764 map by Jacques Nicolas Bellin Before European colonization, the Turks and Caicos Islands...

Lachute

City in Quebec, CanadaLachuteCityLocation within Argenteuil RCMLachuteLocation in central QuebecCoordinates: 45°39′N 74°20′W / 45.650°N 74.333°W / 45.650; -74.333[1]CountryCanadaProvinceQuebecRegionLaurentidesRCMArgenteuilSettled1753ConstitutedApril 30, 1966Government[2] • MayorBernard Bigras-Denis • Federal ridingArgenteuil—La Petite-Nation • Prov. ridingArgenteuilArea[2][3] • T...

 

 

FTTx

Lo schema illustra come le architetture FTTx variano proprio per la distanza tra la fibra ottica e l'utente finale. L'edificio sulla sinistra è la centrale telefonica mentre quello sulla destra è l'edificio servito dalla centrale. I rettangoli tratteggiati rappresentano gli appartamenti o gli uffici all'interno dello stesso edificio. FTTx è l'acronimo della locuzione inglese Fiber to the x che indica un'architettura di rete di telecomunicazioni di livello fisico a banda larga utilizzante l...

 

 

Buddhist temples in Huế

Buddhist temples in Huế have long been an important part of the city's consciousness. The city was founded during the Nam tiến southward expansion of Vietnam in the 16th century and Buddhism was introduced to the lands of the former territory of Champa, which was Hindu. The ruling Nguyễn lords were noted for their patronization of Buddhist temples in the city, something that continued during the Nguyễn dynasty that unified modern Vietnam. Huế was long regarded as a centre of Buddhis...

Sony Ericsson K750

2005 mobile phone This article does not cite any sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Sony Ericsson K750 – news · newspapers · books · scholar · JSTOR (May 2024) (Learn how and when to remove this message)This article's tone or style may not reflect the encyclopedic tone used on Wikipedia. See Wikipedia's guide to writing better articles for sug...

 

 

Gail O'Grady

Questa voce sull'argomento attori statunitensi è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti del progetto di riferimento. Gail Ann O'Grady Gail Ann O'Grady (Detroit, 23 gennaio 1963) è un'attrice statunitense, nota soprattutto per la sua partecipazione alle serie NYPD - New York Police Department, American Dreams e Hellcats, quest'ultima accanto all'attrice e cantante Ashley Tisdale. Indice 1 Filmografia parziale 1.1 Cinema 1.2...