Sirtuin 1

SIRT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSIRT1, SIR2L1, SIR2, hSIR2, SIR2alpha, Sirtuin 1
External IDsOMIM: 604479; MGI: 2135607; HomoloGene: 56556; GeneCards: SIRT1; OMA:SIRT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

23411

93759

Ensembl

ENSG00000096717

ENSMUSG00000020063

UniProt

Q96EB6

Q923E4

RefSeq (mRNA)

NM_001142498
NM_001314049
NM_012238

NM_001159589
NM_001159590
NM_019812

RefSeq (protein)

NP_001135970
NP_001300978
NP_036370

NP_001153061
NP_062786

Location (UCSC)Chr 10: 67.88 – 67.92 MbChr 10: 63.15 – 63.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene.[5][6][7]

SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (Saccharomyces cerevisiae) is Sir2. SIRT1 is an enzyme located primarily in the cell nucleus that deacetylates transcription factors that contribute to cellular regulation (reaction to stressors, longevity).[8][9]

Function

Sirtuin 1 is a member of the sirtuin family of proteins, homologs of the Sir2 gene in S. cerevisiae. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. The protein encoded by this gene is included in class I of the sirtuin family.[6]

Sirtuin 1 is downregulated in cells that have high insulin resistance.[10] Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.[11][12]

In vitro, SIRT1 has been shown to deacetylate and thereby deactivate the p53 protein,[13] and may have a role in activating T helper 17 cells.[14]

Selective ligands

Activators

  • Lamin A is a protein that had been identified as a direct activator of Sirtuin 1 during a study on progeria.[15]
  • Resveratrol has been claimed to be an activator of sirtuin 1,[16] but this effect has been disputed based on the fact that the initially used activity assay, using a non-physiological substrate peptide, can produce artificial results.[17][18] Resveratrol increases the expression of SIRT1, meaning that it does increase the activity of SIRT1, though not necessarily by direct activation.[10] However, resveratrol was later shown to directly activate Sirtuin 1 against non-modified peptide substrates.[19][20] Resveratrol also enhances the binding between Sirtuin 1 and Lamin A.[15] In addition to resveratrol, a range of other plant-derived polyphenols have also been shown to interact with SIRT1.[21]
  • SRT-1720 was also claimed to be an activator,[16] but this now has been questioned.[22]
  • Methylene blue[23] by increasing NADH/NAD+ ratio.
  • Metformin activates both PRKA and SIRT1.[24]

Although neither resveratrol or SRT1720 directly activate SIRT1, resveratrol, and probably SRT1720, indirectly activate SIRT1 by activation of AMP-activated protein kinase (AMPK),[25] which increases NAD+ levels (which is the cofactor required for SIRT1 activity).[26][27] Elevating NAD+ is a more direct and reliable way to activate SIRT1.[27]

Interactions

Sirtuin 1 has been shown in vitro to interact with ERR-alpha[11] and AIRE.[28]

Human Sirt1 has been reported having 136 direct interactions in interactomic studies involved in numerous processes.[29]

Yeast homolog

Sir2 (whose homolog in mammals is known as SIRT1) was the first of the sirtuin genes to be found. It was found in budding yeast, and, since then, members of this highly conserved family have been found in nearly all organisms studied.[30] Sirtuins are hypothesized to play a key role in an organism's response to stresses (such as heat or starvation) and to be responsible for the lifespan-extending effects of calorie restriction.[31][32]

The three letter yeast gene symbol Sir stands for Silent Information Regulator while the number 2 is representative of the fact that it was the second SIR gene discovered and characterized.[33][34]

In the roundworm, Caenorhabditis elegans, Sir-2.1 is used to denote the gene product most similar to yeast Sir2 in structure and activity.[35][36]

Method of action and observed effects

Sirtuins act primarily by removing acetyl groups from lysine residues within proteins in the presence of NAD+; thus, they are classified as "NAD+-dependent deacetylases" and have EC number 3.5.1.[37] They add the acetyl group from the protein to the ADP-ribose component of NAD+ to form O-acetyl-ADP-ribose. The HDAC activity of Sir2 results in tighter packaging of chromatin and a reduction in transcription at the targeted gene locus. The silencing activity of Sir2 is most prominent at telomeric sequences, the hidden MAT loci (HM loci), and the ribosomal DNA (rDNA) locus (RDN1) from which ribosomal RNA is transcribed.

Limited overexpression of the Sir2 gene results in a lifespan extension of about 30%,[38] if the lifespan is measured as the number of cell divisions the mother cell can undergo before cell death. Concordantly, deletion of Sir2 results in a 50% reduction in lifespan.[38] In particular, the silencing activity of Sir2, in complex with Sir3 and Sir4, at the HM loci prevents simultaneous expression of both mating factors which can cause sterility and shortened lifespan.[39] Additionally, Sir2 activity at the rDNA locus is correlated with a decrease in the formation of rDNA circles. Chromatin silencing, as a result of Sir2 activity, reduces homologous recombination between rDNA repeats, which is the process leading to the formation of rDNA circles. As accumulation of these rDNA circles is the primary way in which yeast are believed to "age", then the action of Sir2 in preventing accumulation of these rDNA circles is a necessary factor in yeast longevity.[39]

Starving of yeast cells leads to a similarly extended lifespan, and indeed starving increases the available amount of NAD+ and reduces nicotinamide, both of which have the potential to increase the activity of Sir2. Furthermore, removing the Sir2 gene eliminates the life-extending effect of caloric restriction.[40] Experiments in the nematode Caenorhabditis elegans and in the fruit fly Drosophila melanogaster[41] support these findings. As of 2006, experiments in mice are underway.[31]

However, some other findings call the above interpretation into question. If one measures the lifespan of a yeast cell as the amount of time it can live in a non-dividing stage, then silencing the Sir2 gene actually increases lifespan [42] Furthermore, calorie restriction can substantially prolong reproductive lifespan in yeast even in the absence of Sir2.[43]

In organisms more complicated than yeast, it appears that Sir2 acts by deacetylation of several other proteins besides histones.

In the fruit fly Drosophila melanogaster, the Sir2 gene does not seem to be essential; loss of a sirtuin gene has only very subtle effects.[40] However, mice lacking the SIRT1 gene (the sir2 biological equivalent) were smaller than normal at birth, often died early or became sterile.[44]

Inhibition of SIRT1

Human aging is characterized by a chronic, low-grade inflammation level,[45] and the pro-inflammatory transcription factor NF-κB is the main transcriptional regulator of genes related to inflammation.[46] SIRT1 inhibits NF-κB-regulated gene expression by deacetylating the RelA/p65 subunit of NF-κB at lysine 310.[47][48] But NF-κB more strongly inhibits SIRT1. NF-κB increases the levels of the microRNA miR-34a (which inhibits nicotinamide adenine dinucleotide NAD+ synthesis) by binding to its promoter region.[49] resulting in lower levels of SIRT1.

Both the SIRT1 enzyme and the poly ADP-ribose polymerase 1 (PARP1) enzyme require NAD+ for activation.[50] PARP1 is a DNA repair enzyme, so in conditions of high DNA damage, NAD+ levels can be reduced 20–30% thereby reducing SIRT1 activity.[50]

Homologous recombination

SIRT1 protein actively promotes homologous recombination (HR) in human cells, and likely promotes recombinational repair of DNA breaks.[51] SIRT1-mediated HR requires the WRN protein.[51] WRN protein functions in double-strand break repair by HR.[52] WRN protein is a RecQ helicase, and in its mutated form gives rise to Werner syndrome, a genetic condition in humans characterized by numerous features of premature aging. These findings link SIRT1 function to HR, a DNA repair process that is likely necessary for maintaining the integrity of the genome during aging.[51]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000096717 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020063 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Frye RA (June 1999). "Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity". Biochemical and Biophysical Research Communications. 260 (1): 273–79. doi:10.1006/bbrc.1999.0897. PMID 10381378.
  6. ^ a b "Entrez Gene: SIRT1 sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)".
  7. ^ SIRT1 human gene location in the UCSC Genome Browser.
  8. ^ Sinclair DA, Guarente L (March 2006). "Unlocking the Secrets of Longevity Genes". Scientific American. 294 (3): 48–51, 54–7. Bibcode:2006SciAm.294c..48S. doi:10.1038/scientificamerican0306-48. PMID 16502611.
  9. ^ Fujita Y, Yamashita T (2018). "Sirtuins in Neuroendocrine Regulation and Neurological Diseases". Frontiers in Neuroscience. 12: 778. doi:10.3389/fnins.2018.00778. PMC 6213750. PMID 30416425.
  10. ^ a b Sun C, Zhang F, Ge X, Yan T, Chen X, Shi X, Zhai Q (October 2007). "SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B". Cell Metabolism. 6 (4): 307–19. doi:10.1016/j.cmet.2007.08.014. PMID 17908559.
  11. ^ a b Wilson BJ, Tremblay AM, Deblois G, Sylvain-Drolet G, Giguère V (July 2010). "An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha". Molecular Endocrinology. 24 (7): 1349–58. doi:10.1210/me.2009-0441. PMC 5417470. PMID 20484414.
  12. ^ Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J (April 2009). "AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity". Nature. 458 (7241): 1056–60. Bibcode:2009Natur.458.1056C. doi:10.1038/nature07813. PMC 3616311. PMID 19262508.
  13. ^ EntrezGene 23411 Human Sirt1
  14. ^ Verdin E (December 2015). "NAD⁺ in aging, metabolism, and neurodegeneration". Science. 350 (6265): 1208–13. Bibcode:2015Sci...350.1208V. doi:10.1126/science.aac4854. PMID 26785480. S2CID 27313960.
  15. ^ a b Liu B, Ghosh S, Yang X, Zheng H, Liu X, Wang Z, Jin G, Zheng B, Kennedy BK, Suh Y, Kaeberlein M, Tryggvason K, Zhou Z (December 2012). "Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria". Cell Metabolism. 16 (6): 738–50. doi:10.1016/j.cmet.2012.11.007. PMID 23217256.
  16. ^ a b Alcaín FJ, Villalba JM (April 2009). "Sirtuin activators". Expert Opinion on Therapeutic Patents. 19 (4): 403–14. doi:10.1517/13543770902762893. PMID 19441923. S2CID 20849750.
  17. ^ Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK (April 2005). "Substrate-specific activation of sirtuins by resveratrol". The Journal of Biological Chemistry. 280 (17): 17038–45. doi:10.1074/jbc.M500655200. PMID 15684413.
  18. ^ Beher D, Wu J, Cumine S, Kim KW, Lu SC, Atangan L, Wang M (December 2009). "Resveratrol is not a direct activator of SIRT1 enzyme activity". Chemical Biology & Drug Design. 74 (6): 619–24. doi:10.1111/j.1747-0285.2009.00901.x. PMID 19843076. S2CID 205913187.
  19. ^ Lakshminarasimhan M, Rauh D, Schutkowski M, Steegborn C (March 2013). "Sirt1 activation by resveratrol is substrate sequence-selective". Aging. 5 (3): 151–54. doi:10.18632/aging.100542. PMC 3629287. PMID 23524286.
  20. ^ Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA (March 2013). "Evidence for a common mechanism of SIRT1 regulation by allosteric activators". Science. 339 (6124): 1216–19. Bibcode:2013Sci...339.1216H. doi:10.1126/science.1231097. PMC 3799917. PMID 23471411.
  21. ^ Ajami M, Pazoki-Toroudi H, Amani H, Nabavi SF, Braidy N, Vacca RA, Atanasov AG, Mocan A, Nabavi SM (November 2016). "Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols". Neuroscience and Biobehavioral Reviews. 73: 39–47. doi:10.1016/j.neubiorev.2016.11.022. PMID 27914941. S2CID 3991428.
  22. ^ Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofalo RS, Griffith D, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K (March 2010). "SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1". The Journal of Biological Chemistry. 285 (11): 8340–51. doi:10.1074/jbc.M109.088682. PMC 2832984. PMID 20061378.
  23. ^ Shin SY, Kim TH, Wu H, Choi YH, Kim SG (March 2014). "SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis". European Journal of Pharmacology. 727: 115–24. doi:10.1016/j.ejphar.2014.01.035. PMID 24486702.
  24. ^ Song YM, Lee YH, Kim JW, Ham DS, Kang ES, Cha BS, Lee HC, Lee BW (2015). "Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway". Autophagy. 11 (1): 46–59. doi:10.4161/15548627.2014.984271. PMC 4502778. PMID 25484077.
  25. ^ Joshi T, Singh AK, Haratipour P, Farzaei MH (2019). "Targeting AMPK signaling pathway by natural products for treatment of diabetes mellitus and its complications". Journal of Cellular Physiology. 234 (10): 17212–17231. doi:10.1002/jcp.28528. PMID 30916407. S2CID 85533334.
  26. ^ Farghali H, Kemelo MK, Canová NK (2019). "SIRT1 Modulators in Experimentally Induced Liver Injury". Oxidative Medicine and Cellular Longevity. 2019: 8765954. doi:10.1155/2019/8765954. PMC 6589266. PMID 31281594.
  27. ^ a b Cantó C, Auwerx J (2012). "Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?". Pharmacological Reviews. 64 (1): 166–187. doi:10.1124/pr.110.003905. PMC 3616312. PMID 22106091.
  28. ^ Chuprin A, Avin A, Goldfarb Y, Herzig Y, Levi B, Jacob A, Sela A, Katz S, Grossman M, Guyon C, Rathaus M, Cohen HY, Sagi I, Giraud M, McBurney MW, Husebye ES, Abramson J (July 2015). "The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance". Nature Immunology. 16 (7): 737–45. doi:10.1038/ni.3194. PMID 26006015. S2CID 205369422.
  29. ^ Sharma A, Gautam V, Costantini S, Paladino A, Colonna G (2012). "Interactomic and pharmacological insights on human sirt-1". Frontiers in Pharmacology. 3: 40. doi:10.3389/fphar.2012.00040. PMC 3311038. PMID 22470339.
  30. ^ Frye RA (July 2000). "Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins". Biochemical and Biophysical Research Communications. 273 (2): 793–98. doi:10.1006/bbrc.2000.3000. PMID 10873683.
  31. ^ a b Sinclair DA, Guarente L (March 2006). "Unlocking the secrets of longevity genes". Scientific American. 294 (3): 48–51, 54–57. Bibcode:2006SciAm.294c..48S. doi:10.1038/scientificamerican0306-48. PMID 16502611.
  32. ^ Noriega LG, Feige JN, Canto C, Yamamoto H, Yu J, Herman MA, Mataki C, Kahn BB, Auwerx J (September 2011). "CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability". EMBO Reports. 12 (10): 1069–76. doi:10.1038/embor.2011.151. PMC 3185337. PMID 21836635.
  33. ^ Rine J, Herskowitz I (May 1987). "Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae". Genetics. 116 (1): 9–22. doi:10.1093/genetics/116.1.9. PMC 1203125. PMID 3297920.
  34. ^ North BJ, Verdin E (2004). "Sirtuins: Sir2-related NAD-dependent protein deacetylases". Genome Biology. 5 (5): 224. doi:10.1186/gb-2004-5-5-224. PMC 416462. PMID 15128440.
  35. ^ WormBase Protein Summary: Sir-2.1
  36. ^ http://mediwire.skyscape.com/main/Default.aspx?P=Content&ArticleID=174239 Archived 2007-09-27 at the Wayback Machine "Skyscape Content: Do antiaging approaches promote longevity?". Archived from the original on September 27, 2007. Retrieved July 6, 2016.{{cite web}}: CS1 maint: bot: original URL status unknown (link) Skyscape Content: Do antiaging approaches promote longevity?
  37. ^ The Sir2 protein family from EMBL's InterPro database
  38. ^ a b Chang KT, Min KT (June 2002). "Regulation of lifespan by histone deacetylase". Ageing Research Reviews. 1 (3): 313–26. doi:10.1016/S1568-1637(02)00003-X. PMID 12067588. S2CID 39452909.
  39. ^ a b Kaeberlein M, McVey M, Guarente L (October 1999). "The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms". Genes & Development. 13 (19): 2570–80. doi:10.1101/gad.13.19.2570. PMC 317077. PMID 10521401.
  40. ^ a b EntrezGene 34708 Drosophila Sir2
  41. ^ Rogina B, Helfand SL (November 2004). "Sir2 mediates longevity in the fly through a pathway related to calorie restriction". Proceedings of the National Academy of Sciences of the United States of America. 101 (45): 15998–6003. Bibcode:2004PNAS..10115998R. doi:10.1073/pnas.0404184101. PMC 528752. PMID 15520384.
  42. ^ Fabrizio P, Gattazzo C, Battistella L, Wei M, Cheng C, McGrew K, Longo VD (November 2005). "Sir2 blocks extreme life-span extension". Cell. 123 (4): 655–67. doi:10.1016/j.cell.2005.08.042. PMID 16286010. S2CID 1276690.
  43. ^ Kaeberlein M, Kirkland KT, Fields S, Kennedy BK (September 2004). "Sir2-independent life span extension by calorie restriction in yeast". PLOS Biology. 2 (9): E296. doi:10.1371/journal.pbio.0020296. PMC 514491. PMID 15328540.
  44. ^ McBurney MW, Yang X, Jardine K, Hixon M, Boekelheide K, Webb JR, Lansdorp PM, Lemieux M (January 2003). "The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis". Molecular and Cellular Biology. 23 (1): 38–54. doi:10.1128/MCB.23.1.38-54.2003. PMC 140671. PMID 12482959.
  45. ^ Franceschi C, Campisi J (June 2014). "Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases". The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 69 (S1): S4 – S9. doi:10.1093/gerona/glu057. PMID 24833586.
  46. ^ Lawrence T (December 2009). "The nuclear factor NF-kappaB pathway in inflammation". Cold Spring Harbor Perspectives in Biology. 1 (6): a001651. doi:10.1101/cshperspect.a001651. PMC 2882124. PMID 20457564.
  47. ^ Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW (June 2004). "Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase". The EMBO Journal. 23 (12): 2369–80. doi:10.1038/sj.emboj.7600244. PMC 423286. PMID 15152190.
  48. ^ Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A (October 2013). "Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders". Cellular Signalling. 25 (10): 1939–48. doi:10.1016/j.cellsig.2013.06.007. PMID 23770291.
  49. ^ de Gregorio E, Colell A, Morales A, Marí M (2020). "Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease". International Journal of Molecular Sciences. 21 (11): 3858. doi:10.3390/ijms21113858. PMC 7312021. PMID 32485811.
  50. ^ a b Chung HT, Joe Y (2014). "Antagonistic crosstalk between SIRT1, PARP-1, and -2 in the regulation of chronic inflammation associated with aging and metabolic diseases". Integrative Medicine Research. 3 (4): 198–203. doi:10.1016/j.imr.2014.09.005. PMC 5481777. PMID 28664098.
  51. ^ a b c Uhl M, Csernok A, Aydin S, Kreienberg R, Wiesmüller L, Gatz SA (2010). "Role of SIRT1 in homologous recombination". DNA Repair (Amst.). 9 (4): 383–93. doi:10.1016/j.dnarep.2009.12.020. PMID 20097625.
  52. ^ Thompson LH, Schild D (2002). "Recombinational DNA repair and human disease". Mutat. Res. 509 (1–2): 49–78. doi:10.1016/s0027-5107(02)00224-5. PMID 12427531.

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Canadian Tire

Canadian retail company Canadian Tire Corporation, LimitedHead office for Canadian Tire at the Canada Square Complex on Yonge StreetTrade nameCanadian TireCompany typePublicTraded asTSX: CTC (voting)TSX: CTC.A (non-voting)IndustryRetailFoundedOctober 24, 1922; 101 years ago (1922-10-24)FoundersAlfred Jackson BillesJohn William BillesHeadquarters2180 Yonge StreetToronto, OntarioM4P 2V8Number of locations1,686 locations: 503 Canadian Tire stores, 91 PartSource stores...

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Мифическое время

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List of golf courses in the Philippines

This article uses bare URLs, which are uninformative and vulnerable to link rot. Please consider converting them to full citations to ensure the article remains verifiable and maintains a consistent citation style. Several templates and tools are available to assist in formatting, such as reFill (documentation) and Citation bot (documentation). (June 2022) (Learn how and when to remove this message) A golf course in San Jose del Monte, Bulacan. This is a list of golf courses in the Philippin...

La Désirade

This article is about the island of La Désirade. For the administrative commune which includes the island, see La Désirade (commune). This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: La Désirade – news · newspapers · books · scholar · JSTOR (June 2008) (Learn how and when to remove this message) Satellite ...

 

صربيا

هذه المقالة عن جمهورية صربيا. لتصفح عناوين مشابهة، انظر صربيا (توضيح).   جمهورية صربيا Република Србија Republika Srbija  (صربية) صربياعلم صربيا صربياشعار صربيا صربيا النشيد: النشيد الوطني الصربي الأرض والسكان إحداثيات 43°57′00″N 20°56′00″E / 43.95°N 20.933333333333°E / 43.95; 20.9...